99% Pge1 Prostaglandin E1

What is Prostaglandin E1? Alprostadil (Prostglandin E1) is used to treat erectile dysfunction (ED) in adult males. The efficacy of alprostadil in treating ED varies with the cause; response rate is generally lower in patients with ED due to mixed etiologies compared to those with ED due to neurogenic, psychogenic, or vasculogenic causes. Additionally, PGE1 has been shown to affect protein kinase C (PKC), calcium movement, and adenylate cyclase yielding a multitude of physiological effects. Prostaglandin E1 will prevent the ductus arteriosus from closing and reestablish ductal patency if closure has already occurred, and thereby increase PaO2, and mitigate the onset of metabolic acidosis. This drug is indicated for the temporary management of the neonate with ductus-dependent congenital heart disease while awaiting transfer to a tertiary care nursery for evaluation and surgical therapy. It is also used to stabilize a neonate's condition until surgery can be completed.

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