PGE1 exerts a number of effects, including systemic vasodilation, inhibition of platelet aggregation, and stimulation of intestinal motility. PGE1 relaxes isolated smooth muscle cells contracted by norepinephrine. It has become widely used in the treatment of ED. Alprostadil binds with PGE receptors and results in a cyclic adenosine monophosphate (cAMP) mediated smooth muscle relaxation. Little is known about the pharmacokinetics of PGE1, but it is believed that as much as 80% is metabolized in one pass through the lungs. Such rapid degradation probably accounts for its lack of significant cardiovascular side effects when administered intracavernosally. PGE1 can also be metabolized in the penis.

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with heart problems. This medication guide addresses only the adult male use of alprostadil in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis which increases blood flow, causing an erection.

Alprostadil cream  is a prescription-only treatment for erectile dysfunction which was launched in the UK in June 2014. alprostadil cream  is an alternative treatment for men who have failed to achieve satisfactory results with tablet treatments (PDE5 inhibitors), or for men who cannot tolerate the side effects of these tablets and who cannot take them for medical reasons.

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