High Quality Raws Powder Hot-Selling Cosmetic Grade Best Price Pharmaceutical Chemicals Linaclotide CAS 851199 -59-2
China High Quality Raws Powder Hot-Selling Cosmetic Grade Best Price Pharmaceutical Chemicals Linaclotide CAS 851199-59-2, Find details about China 99% Purity, Chemical Materials from High Quality Raws Powder Hot-Selling Cosmetic Grade Best Price Pharmaceutical Chemicals Linaclotide CAS 851199-59-2
Basic Info.
Model NO.
851199-59-2
Appearance
Solid Powder
Molecular Formula
C59h79n15o21s6
Grade
Pharmaceutical Grade
Trademark
Wingroup
Transport Package
Drum / Aluminum Foil Bag
Origin
Wuhan, China
Model NO.
851199-59-2
Appearance
Solid Powder
Molecular Formula
C59h79n15o21s6
Grade
Pharmaceutical Grade
Trademark
Wingroup
Transport Package
Drum / Aluminum Foil Bag
Origin
Wuhan, China
Product Desciption
| CAS NO: | 851199-59-2 |
| Product Name: | Linaclotide |
| Synonyms: | Linacllotide;Linaclotide;Linaelotide Acetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide) |
| Molecular Formula: | C59H79N15O21S6 |
| Molecular Weight: | 1526.74 |
| Boiling point: | 2045.0±65.0 °C(Predicted) |
| Density: | 1.60 |
| Appearance: | Solid powder |
| Purity: | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition: | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition: | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility: | Soluble in DMSO. |
Description:
In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.
In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.
Uses:
Linaclotide is an effective and selective guanylate cyclase C agonist; it was developed to treat constipation-type irritable bowel syndrome (IBS-C) and chronic constipation.
Adverse effects:
The US label has a black box warning to not use linaclotide in children less than 6 years old and to avoid in people from 6 to 18 years old, due to the risk of serious dehydration.
More than 10% of people taking linaclotide have diarrhea. Between 1% and 10% of people have decreased appetite, dehydration, low potassium, dizziness when standing up too quickly, nausea, vomiting, urgent need to defecate, fecal incontinence, and bleeding in their colon, rectum, and anus.
Linaclotide is an effective and selective guanylate cyclase C agonist; it was developed to treat constipation-type irritable bowel syndrome (IBS-C) and chronic constipation.
Adverse effects:
The US label has a black box warning to not use linaclotide in children less than 6 years old and to avoid in people from 6 to 18 years old, due to the risk of serious dehydration.
More than 10% of people taking linaclotide have diarrhea. Between 1% and 10% of people have decreased appetite, dehydration, low potassium, dizziness when standing up too quickly, nausea, vomiting, urgent need to defecate, fecal incontinence, and bleeding in their colon, rectum, and anus.
Q1:Can l get some samples?
A:Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2:Which kind of payment terms do you accept?
A: Payment by T/T, Western Union or Bitcoin.
Q3:Which transportation do we use?
A:Samples could be DHL,UPS,TNT,EMS, Fedex, and so on.For mass orders, it will be delivered by air or sea.
Q4:How about your delivery time?
Generally, it will take 3 to 5 days after receiving your advance payment.
Q5:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real qualityproblem caused by us, we will send you free goods for replacement or refund your loss.
Q6:How can we trust you?
A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited ourcompany on-spot and approved our credit.
Q7:Do you test all your goods before delivery?
A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if youneed are highly welcomed.
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