Linaclotide reduces visceral pain and increases gastrointestinal transport speed, and in humans, it also increases colon transport speed.The result of GC-C activation is an increased concentration of cGMP (cyclic guanylate) inside and outside the cell.Extracellular cGMP can reduce the activity of Chemicalbook dimensional in painful nerve fibers and relieve visceral pain in model animals.Intracellular cGMP increases the secretion of chloride and bicarb in the lumen of the small intestine by activating CFTR (Cystic Fibrosis Transmembrane Conduction regulator), which ultimately leads to increased secretion of intestinal fluid and increased transport speed in the small intestine.

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