Supply Wholesale Price CAS 107648-80-6 Pure Cefepime Hydrochloride Powder
China Supply Wholesale Price CAS 107648-80-6 Pure Cefepime Hydrochloride Powder, Find details about China CAS 107648-80-6, Cefepime Hydrochloride Powder from Supply Wholesale Price CAS 107648-80-6 Pure Cefepime Hydrochloride Powder
Basic Info.
Model NO.
PHA001
Trademark
ALLRIGHT G. C.
Transport Package
as Required
Specification
25kgs packaging Fiber drum outside and plastic bag
Origin
Shandong
Model NO.
PHA001
Trademark
ALLRIGHT G. C.
Transport Package
as Required
Specification
25kgs packaging Fiber drum outside and plastic bag
Origin
Shandong
Product Desciption
English name | Cefepime Hydrochloride powder |
Purity | 99% |
Appearance | White powder |
Odor | Characteristic |
CAS | 107648-80-6 |
Test Method | HPLC |
Cefepime hydrochloride is used to treat lower respiratory tract, urinary tract, skin and soft tissues, biliary tract, abdominal and pelvic cavity, gynecological and obstetric infections, and sepsis caused by sensitive bacteria. It is also used for empirical treatment of moderate and severe bacterial pneumonia.
Cefepime is indicated for the treatment of the following infections caused by susceptible bacteria:
1) Lower respiratory tract infections, such as pneumonia, bronchitis, etc. 2) Urinary system infections, such as pyelonephritis. 3) Skin and soft tissueinfections. 4) Intraperitoneal infections (including peritonitis and biliary infections, etc.). 5) Obstetrics and Gynecology infection. 6) Septicemia.
Pharmacological action
1. Cefepime hydrochloride is a fourth-generation cephalosporin whose antibacterial mechanism is to inhibit the synthesis and metabolism of bacterial cell wall by binding to one or more penicillin-binding proteins (PBPs) of bacterial cells, thereby exerting an antibacterial effect. Cefepime is characterized by high antibacterial activity, stable β-lactamase, especially chromosome-mediated Richmond-sykes type I β-lactamase, and very sensitive to Gram-negative bacilli producing type I β-lactamase Strong antibacterial activity. Cefepime has antibacterial activity against Enterobacter, Citrobacter and Serratia
producing type I β-lactamase over third-generation cephalosporins such as ceftazidime; antibacterial against Pseudomonas aeruginosa The effect is similar to or slightly worse than ceftazidime; the antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus is also enhanced than that of the third-generation cephalosporin.
producing type I β-lactamase over third-generation cephalosporins such as ceftazidime; antibacterial against Pseudomonas aeruginosa The effect is similar to or slightly worse than ceftazidime; the antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus is also enhanced than that of the third-generation cephalosporin.
2. Gram-negative aerobic bacteria: Pseudomonas (including Pseudomonas aeruginosa, Pseudomonas putida), Escherichia coli, Klebsiella, Enterobacter (including Enterobacter cloacae, gas production) Enterobacter), variant bacillus (including Proteus mirabilis, common Proteus), citrate bacteria, Campylobacter jejuni, Haemophilus haemophilus, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, gonorrhea Neisseria, Neisseria meningitidis, Salmonella, Serratia, Shigella, Yersinia enterocolitica.
3. Anaerobic bacteria: Bacteroides, Clostridium perfringens, Clostridium, Streptococcus pneumoniae, and Weirong cocci. Cefepime hydrochloride has no antibacterial activity against most enterococci (such as Enterococcus faecalis, methicillin-resistant Staphylococcus), Pseudomonas maltophilia, Bacteroides fragilis, and Clostridium difficile.
Tests | Specifications | Result |
Description | White powder | Meets the requirements |
Identification | Meets the requirements | Meets the requirements |
Water | 3.0-4.% | 3.2% |
Crystallinity | Meets the requirements | Meets the requirements |
Bacterial endotoxins | <0.04EU/mg | Meets the requirements |
Residue on Ignition | ≤0.1% | 0.08% |
Sterility | Meets the requirements | Meets the requirements |
N-methylpyrrolidine | ≤0.3% | Not detected |
Heavy Metals | ≤20ppm | <20ppm |
Sterile | conform | complies |
Related compounds | ||
Cefepime related compound A | ≤0.3% | Not detected |
Cefepime related compound B | ≤0.2% | Not detected |
Any other impurity | ≤0.1% | 0.04 |
Assay | 825~911ug/mg | 856 ug/mg |
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