Hesperidin is a flavanone glycoside (flavonoid) found abundantly in citrus fruits. Its aglycone form is called hesperetin.Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition it contributes to the integrity of the blood vessels.Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has antiinflammatory effects.

 

Safety Concerns

Hesperidin is possibly safe for most people when used for less than three months. Side effects include stomach pain and upset, diarrhea, and headache.Do not use hesperidin if You are pregnant or breast-feeding.

Dosage Information

The following doses have been studied in scientific research: For the treatment of hemorrhoids inside the anus: 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days. For preventing the return of hemorrhoids inside the anus: 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months. For the treatment of leg ulcers caused by poor blood circulation (venous stasis ulcers): a combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months.

1.Hesperidins has antioxidant, anti inflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering actions.

2.Hesperidins can inhibit following enzymes: Phospholipase A2, lipoxygenase, HMG-CoA reductase and cyclo-oxygenase. 

3.Hesperidins improve the health of capillaries by reducing the capillary permeability. 

4.Hesperidins are used to reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells. The possible anticancer activity of hesperidins could be explained y the inhibition of polyamine synthesis.

5.Orange Flavone has the properties such as unique aromaticity, good water bath, and obvious pharmacological action 

6.It can excite the heart and shrink the blood vessel, and then causes the hypertension