1.Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.

2.Diosmin increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.

3.Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.

4.Diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.

5.At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.

6.Diosmin reduces the expression of endothelial adhesion molecules,and inhibits the adhesion, migration, and activation of leukocytes at the capillary level.Diosmin leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins.

 1.Diosmin Hesperidin is Applied in food field, it is used as a flavor enhancer and sweetener in a wide variety of alcoholicbeverage, dessert foods and savory foods;

 2.Diosmin Hesperidin is Applied in cosmetics, it can added into toothpaste and mouth wash ;

 3.Diosmin Hesperidin is Applied in pharmaceutical field, it is mainly used to reducing the bitterness of in form.