2019 China Factory Supply CAS 94-09-7 Benzocaine, Find details about China Benzocaine from 2019 China Factory Supply CAS 94-09-7 Benzocaine
Product Name: | Benzocaine |
Other Name | Benzocainum; ethyl 4-aminobenzene carboxylate |
CAS: | 94-09-7 |
HS Code | 30013006 |
MF: | C9H11NO2 |
MW: | 165.189 |
Melting point: | 88-90 °C |
Boiling point: | 310.7±15.0 °C at 760 mmHg |
Flash point: | 164.2±17.9 °C |
Density | 1.1±0.1 g/cm3 |
Shelf Life | 3 years |
Appearance | White powder |
Brand Name: | Oriherb |
Form | Powder |
Place of Origin: | Shaanxi, China (Mainland) |
Packaging: | Bottle, Can, Drum, Plastic Contain |
Standard: | USP EP JP etc. |
Introduction: | Benzocaine is a colorless trapezial crystal. Its melting point is 92ºC (88-90ºC), boiling point is 183-184°C (1.87kPa). 1g of this drug is soluble in about 2500ml water, 5ml ethanol, 2ml chloroform, 4ml ether or 30-50ml almond oil and olive oil, and it is also soluble in dilute acid. It is stable in air, odorless, and slightly bitter. Benzocaine is a lipid-soluble surface anesthetic, and it weaker than other local anesthetics such as lidocaine and tetracaine, so it will not cause any discomfort due to its anesthetizing effects when acting on mucosa. Benzocaine is a type of drug with relatively strong lipid-solubility and will bind with mucosa and the fatty layer of skin, but it will not easily penetrate into the body and cause poisoning. Benzocaine can be used as a precursor for Ossur imitation, orthocaine, and procaine. It is also used as a local anesthetic and can stop pain and itching. It is mainly used in pain and itch prevention on wounds, ulcer surfaces, mucous membrane surfaces and hemorrhoids. Its paste form can also lubricate and stop pain for the nasopharynx and endoscope. Benzocaine's aural solution is used to alleviate acute congestion, concentrated otitis externa, and the pain and itching of swimming otitis. Benzocaine is also effective for toothaches, sore throat, oral ulcers, all kinds of hemorrhoids, anal fissures, and vulvar itching. Benzocaine can be used as a male sex organ numbing agent to slow ejaculation. It can also be used as a numbing lubricant for the pharynx and endoscope, and it can be used as a UV absorbing agent for cosmetics. |
1. Benzocaine is a local anaesthetic of the ester type with a poor solubility in water. The drug benzocaine is normally used as a topical pain reliever or as a common ingredient in cough drops. Benzocaine is used in multiple forms including lotion, gel, liquid, lozenges, and sprays. When Benzocaine is applied in any form it temporarily numbs or blocks the nerve endings, which leads to a decreases in the amount of pain. It is used in cattle, sheep, swine and horses for local and prolonged low epidural anaesthesia. Standard therapeutic doses of benzocaine ranged from 150 to 750 mg per animal. Benzocaine is also currently used as surface anaesthetic as ointments (0.5% benzocaine) for wounds and ulcerated surfaces in horses, cattle and sheep applied twice a day until healing.
2. A commonly used topical pain reliever. Main active ingredient in anesthetic ointments.
3. Anesthetic;Na+ channel blocker
4. Benzocaine acts on the central nervous system, cardiovascular system, neuromuscular junctions and ganglion synapse. Its mechanism of action is to prevent the generation and conduction of the nerve impulse. Local anaesthetics block conduction by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+ that is produced by a slight depolarisation. This action of local anaesthetics is due to their direct interaction with voltage-sensitive Na+ channels. Benzocaine is mainly hydroxylated in the metabolite para-aminobenzoic acid (PABA) that inhibits the action of sulphonamides.
5. Benzocaine is distributed in the body, crosses the placenta and is metabolised in the liver and in the plasma by non-specific cholinesterases. Benzocaine and its main metabolite (para-aminobenzoic acid) are excreted into urine.
6. Benzocaine appears as a moderately toxic compound after single administration. The acute intraperitoneal LD50 value was 216 mg/kg bw in mice. Benzocaine may induce methemoglobinemia in several species such as sheep, cats and dogs.1.Over the counter throat lozenges such as Cepacol.
2.Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
3.Some previous diet products such as Ayds.
4.Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
5.Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
Product Name | CAS NO. | Purity |
Benzocaine | 94-09-7 | 99% |
Benzocaine hydrochloride | 23239-88-5 | 99% |
Tetracaine hydrochloride | 136-47-0 | 99% |
Procaine | 59-46-1 | 99% |
Tetracaine | 94-24-6 | 99% |
Pramoxine Hydrochloride | 637-58-1 | 99% |
Procaine HCl | 51-05-8 | 99% |
Procainamide hydrochloride | 614-39-1 | 99% |
Lidocaine | 137-58-6 | 99% |
Dibucaine hydrochloride | 61-12-1 | 99% |
Cinchocaine | 85-79-0 | 99% |
Prilocaine | 721-50-6 | 99% |
Propitocaine hydrochloride | 1786-81-8 | 99% |
Proparacaine hydrochloride | 5875-06-9 | 99% |
Lidocaine hydrochloride | 73-78-9 | 99% |
Articaine hydrochloride | 23964-57-0 | 99% |
Levobupivacaine hydrochloride | 27262-48-2 | 99% |
Ropivacaine hydrochloride | 132112-35-7 | 99% |
Bupivacaine | 2180-92-9 | 99% |
Bupivacaine hydrochloride | 14252-80-3 | 99% |
Mepivacaine hydrochloride | 1722-62-9 | 99% |
Dioxopromethazine HCL | 13754-56-8 | 99% |