CAS 60-82-2 Factory Supply Apple Peel Extract Phloretin Powder Phloretin
China CAS 60-82-2 Factory Supply Apple Peel Extract Phloretin Powder Phloretin, Find details about China Phloretin, Apple Peel Extract Phloretin from CAS 60-82-2 Factory Supply Apple Peel Extract Phloretin Powder Phloretin
Basic Info.
Model NO.
60-82-2
Product Name
Phloretin
CAS Number
60-82-2
Inci Name
Phloretin
Molecular Weight
274.269g/Mol
Molecular Formula
C15h14o5
Appearance
Red Brown to White Powder
Particle Size
98% Through 80 Mesh
Extraction Type
Solvent Extraction
Variety
Apple Extract
Test Method
HPLC
Latin Name
Malus Domestica
Trademark
Mainherb
Transport Package
1kg, 25kg
Specification
10%-98%
Origin
China
Model NO.
60-82-2
Product Name
Phloretin
CAS Number
60-82-2
Inci Name
Phloretin
Molecular Weight
274.269g/Mol
Molecular Formula
C15h14o5
Appearance
Red Brown to White Powder
Particle Size
98% Through 80 Mesh
Extraction Type
Solvent Extraction
Variety
Apple Extract
Test Method
HPLC
Latin Name
Malus Domestica
Trademark
Mainherb
Transport Package
1kg, 25kg
Specification
10%-98%
Origin
China
Product Desciption
1. Phloretin Overview
Phloretin is a plant polyphenol with a dihydrochalcone structure. It is present in the peel and root bark of succulent fruits such as apples and pears, and in various vegetable juices. We is extracted from high-quality apple bark and peel, and is cosmetic raw material of 98% specification. Phloretin has abundant biological activities, such as anti-oxidation, anti-tumor, blood sugar lowering, blood vessel protection, etc. And Phloretin can inhibit tyrosinase activity, enhance skin permeability. It also helps other whitening ingredients to enter the skin to exert their biological activity. At the same time, Phloretin can scavenge free radicals, reduce the keratinocytes damage caused by ultraviolet rays; and it also has antibacterial activity. It has many beauty effects including anti-aging, whitening skin, anti-inflammation, and removing acne. Phloretin can dilute pigmentation and whiten skin. Its effect is better than other common whitening agents such as kojic acid and arbutin. It is a new favorite whitening agent in cosmetics market.
2.Phloretin Botanical Source
Apple (Latin name: Malus domestica) is rosaceae plant of the genus apple subfamily. The plant is deciduous tree. Apple is native to central and southeast Europe, central and western Asia, and Sinkiang of China. Apple trees grow well in cool, dry temperate regions. They are mainly distributed in the Loess Plateau, Bohai Bay, Yellow River and Southwest Plateau. China is the world's largest producer and consumer of apple. Overseas countries such as the United States, Turkey, Italy, France, Poland, Germany and Russia also have large areas of apple trees. Apple is rich in carbohydrates, vitamins and micronutrients. It is given the nickname "fruit of wisdom" and "fruit of memory". It can be used for juicing and brewing.
3.Specifications
4. Phloretin Manufacturer Flow Chart
The research and development of whitening agents is mainly dominated by inhibition of tyrosinase activity. Phloretin can inhibit the activity of tyrosinase. Its IC50 is 37.5 μmol/L. Study has found that the inhibition rate of 0.3% Phloretin on tyrosinase is as high as 98.2%. Its IC50 is 0.05%. Its inhibitory effect on tyrosinase is superior to the common whitening agents (kojic acid and arbutin). And further study shows Phloretin can greatly improve the inhibition rate to 100%, when blending with common tyrosinase inhibitor.
2.Anti-inflammation and anti-bacteria
Studies have shown that Phloretin can inhibit the production of inflammatory factors, chemokine factors and differentiation factors. It has a certain anti-inflammatory effect; and it is also a flavonoid compound with antibacterial activity. Phloretin can inhibit the ability of monocytes to adhere to keratinocytes. It blocks the phosphorylation of signal protein kinase AKT and MAPK. Thus it can exert the anti-inflammatory effect. On the one hand, Phloretin acts on the enzyme protein system in bacteria; and it affects the energy metabolism of bacteria. On the other hand, it interferes with proteins synthesis inside the cells, which causes the metabolic disorders inside the cells, and finally leads to the death of bacteria.
3.Sun block
Studies have found that Phloretin not only absorbs UV rays directly, but also enhances the expression of nucleotide resection repair genes. Also it slows the formation of pyrimidine dimers induced by UVB, the degradation of glutathione and cell death. Phloretin reduces the damage of ultraviolet to keratinocytes. Addition of Phloretin to the basic formulation of cosmetics can improve the SPF and SPA values of cosmetics. In addition, a mixture of Phloretin, VC and ferulic acid can protect human skin from UV damage. It can provide light protection for human skin.
4.Anti-oxidation
Phloretin is a flavonoid compound with dihydrochalcone structure. It has 4 phenolic hydroxyl groups. Its unique structure determines its strong antioxidant activity. In vitro experiment indicates that Phloretin has the ability to inhibit mitochondrial lipid per-oxidation; and it removes DPPH and ABTS free radicals. Its antioxidant mass concentration of grease is 10.30mg/L. Phloretin itself not only has antioxidant effect, but also can be combined with existing antioxidants to improve the anti-oxidation effect.
5.Moisturizing
In recent years, researchers have found that plant-derived compounds containing hydroxyl, carboxyl and other polar groups have a moisturizing effect. The four hydroxyl groups contained in the Phloretin molecules can form hydrogen bonds with water molecules. It can absorb water and have potential moisturizing effect. Therefore, Phloretin can also be used as a natural moisturizer in moisturizing cosmetics.
6.Anti-hair loss
Soybean adipose oxygenase is one of the important enzymes in the lipid oxidation process. And it is also involved in skin's inflammatory reaction; it is one of important enzymes that affects hair loss. Foreign studies have shown that Phloretin can inhibit the activity of soybean adipose oxygenase. Thereby it reduces hair loss due to premature entry into senility. Thus, Phloretin can be added to shampoo and conditioner as a raw material for anti-hair loss.
6. Pharmacological studies of Phloretin and cosmetics
7. Phloretin Characteristic
1.Use high-quality apple tree bark and peel as raw material;
2.Environment protection: no emission of hazardous substances in the extraction process;
3.Phloretin's color is more white, and its purity is higher;
4.Phloretin has a good solubility. Its water solution is clear and transparent; it is easy to be absorbed by skin.
8. Phloretin Application and Reference Dosage
Phloretin is widely used in facial mask, emulsion, essence, face cream, sunscreen, shampoo, conditioner and other types of cosmetics.
9. Phloretin Reference Formula
Freckle removing toner
Phloretin is a plant polyphenol with a dihydrochalcone structure. It is present in the peel and root bark of succulent fruits such as apples and pears, and in various vegetable juices. We is extracted from high-quality apple bark and peel, and is cosmetic raw material of 98% specification. Phloretin has abundant biological activities, such as anti-oxidation, anti-tumor, blood sugar lowering, blood vessel protection, etc. And Phloretin can inhibit tyrosinase activity, enhance skin permeability. It also helps other whitening ingredients to enter the skin to exert their biological activity. At the same time, Phloretin can scavenge free radicals, reduce the keratinocytes damage caused by ultraviolet rays; and it also has antibacterial activity. It has many beauty effects including anti-aging, whitening skin, anti-inflammation, and removing acne. Phloretin can dilute pigmentation and whiten skin. Its effect is better than other common whitening agents such as kojic acid and arbutin. It is a new favorite whitening agent in cosmetics market.
| Product Name | CAS Number | INCI Name | |
| Phloretin | 60-82-2 | Phloretin | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| 274.269g/mol | C15H14O5 |  | |
Apple (Latin name: Malus domestica) is rosaceae plant of the genus apple subfamily. The plant is deciduous tree. Apple is native to central and southeast Europe, central and western Asia, and Sinkiang of China. Apple trees grow well in cool, dry temperate regions. They are mainly distributed in the Loess Plateau, Bohai Bay, Yellow River and Southwest Plateau. China is the world's largest producer and consumer of apple. Overseas countries such as the United States, Turkey, Italy, France, Poland, Germany and Russia also have large areas of apple trees. Apple is rich in carbohydrates, vitamins and micronutrients. It is given the nickname "fruit of wisdom" and "fruit of memory". It can be used for juicing and brewing.
3.Specifications| Product Name | Specification | Color |
| Phloretin | 98% | White |
| Items | Specification |
| Assay | ≥98% |
| Appearance | White powder |
| Physical Characteristics | |
| Particle Size | 98% through 80 mesh |
| Moisture | ≤1.00% |
| Ash Content | ≤1.00% |
| Heavy Metals | |
| Heavy metals | ≤10ppm |
| Arsenic | ≤1ppm |
| Lead | ≤1ppm |
| Microbiological Tests | |
| Total Plate count | ≤1000cfu/g |
| Yeast & mold | ≤100cfu/g |
| Escherichia coli | Negative |
| Staphylococcus | Negative |
| Salmonella | Negative |
5. Phloretin Benefits
1.Skin-whiteningThe research and development of whitening agents is mainly dominated by inhibition of tyrosinase activity. Phloretin can inhibit the activity of tyrosinase. Its IC50 is 37.5 μmol/L. Study has found that the inhibition rate of 0.3% Phloretin on tyrosinase is as high as 98.2%. Its IC50 is 0.05%. Its inhibitory effect on tyrosinase is superior to the common whitening agents (kojic acid and arbutin). And further study shows Phloretin can greatly improve the inhibition rate to 100%, when blending with common tyrosinase inhibitor.
2.Anti-inflammation and anti-bacteria
Studies have shown that Phloretin can inhibit the production of inflammatory factors, chemokine factors and differentiation factors. It has a certain anti-inflammatory effect; and it is also a flavonoid compound with antibacterial activity. Phloretin can inhibit the ability of monocytes to adhere to keratinocytes. It blocks the phosphorylation of signal protein kinase AKT and MAPK. Thus it can exert the anti-inflammatory effect. On the one hand, Phloretin acts on the enzyme protein system in bacteria; and it affects the energy metabolism of bacteria. On the other hand, it interferes with proteins synthesis inside the cells, which causes the metabolic disorders inside the cells, and finally leads to the death of bacteria.
3.Sun block
Studies have found that Phloretin not only absorbs UV rays directly, but also enhances the expression of nucleotide resection repair genes. Also it slows the formation of pyrimidine dimers induced by UVB, the degradation of glutathione and cell death. Phloretin reduces the damage of ultraviolet to keratinocytes. Addition of Phloretin to the basic formulation of cosmetics can improve the SPF and SPA values of cosmetics. In addition, a mixture of Phloretin, VC and ferulic acid can protect human skin from UV damage. It can provide light protection for human skin.
4.Anti-oxidation
Phloretin is a flavonoid compound with dihydrochalcone structure. It has 4 phenolic hydroxyl groups. Its unique structure determines its strong antioxidant activity. In vitro experiment indicates that Phloretin has the ability to inhibit mitochondrial lipid per-oxidation; and it removes DPPH and ABTS free radicals. Its antioxidant mass concentration of grease is 10.30mg/L. Phloretin itself not only has antioxidant effect, but also can be combined with existing antioxidants to improve the anti-oxidation effect.
5.Moisturizing
In recent years, researchers have found that plant-derived compounds containing hydroxyl, carboxyl and other polar groups have a moisturizing effect. The four hydroxyl groups contained in the Phloretin molecules can form hydrogen bonds with water molecules. It can absorb water and have potential moisturizing effect. Therefore, Phloretin can also be used as a natural moisturizer in moisturizing cosmetics.
6.Anti-hair loss
Soybean adipose oxygenase is one of the important enzymes in the lipid oxidation process. And it is also involved in skin's inflammatory reaction; it is one of important enzymes that affects hair loss. Foreign studies have shown that Phloretin can inhibit the activity of soybean adipose oxygenase. Thereby it reduces hair loss due to premature entry into senility. Thus, Phloretin can be added to shampoo and conditioner as a raw material for anti-hair loss.
6. Pharmacological studies of Phloretin and cosmetics
| Test Item | Concentration | Result |
| Elimination of free radical DPPH | 32umol/L | Elimination rate: 74.6% |
| Inhibition of lipid peroxidation | 13umol/L | Inhibition rate: 53% |
| Promotion of collagen 4 production | 25ug/mL | Promotion rate: 201.6±20.6 (blank 100) |
| Protection against apoptosis of keratinocytes | 400ug/mL | Protection rate:51.3%v9.6% |
| Promotion of ceramide production | 2umol/L | Promotion rate: 164(blank 100) |
| Inhibition of tyrosinase activity | 0.05% | Inhibition rate: 82.2% |
| Inhibition of hyaluronidase activity | 100ug/mL | Inhibition rate: 93.5% |
| Inhibition of 5 α reductase activity | IC50: 84.3ug/mL | |
| Inhibition of activity of mmp-1 metalloproteinase | 5umol/L | Inhibition rate: 78% |
| Inhibition of interleukin-4 production | IC50: >30umol/L | |
| Inhibition of activity of hexosaminidase | 100ug/mL | Inhibition rate: 93.5% |
| Inhibition of moisture evaporation through epidermis by applying Phloretin | 50umol/L | Inhibition rate: 25%(compare to blank) |
1.Use high-quality apple tree bark and peel as raw material;
2.Environment protection: no emission of hazardous substances in the extraction process;
3.Phloretin's color is more white, and its purity is higher;
4.Phloretin has a good solubility. Its water solution is clear and transparent; it is easy to be absorbed by skin.
8. Phloretin Application and Reference Dosage
Phloretin is widely used in facial mask, emulsion, essence, face cream, sunscreen, shampoo, conditioner and other types of cosmetics.
| Product | Reference Dosage |
| Phloretin 98% | 0.3%-2.0% |
Freckle removing toner
| Ingredient | Content(%) | Ingredient | Content(%) |
| Phloretin | 0.05 | Methylparaben | 0.2 |
| Ethanol | 3.0 | water | Add to 100 |
| Glycerin | 0.5 | ||
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