China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8

China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8, Find details about China Atorvastatin Calcium, Atorvastatin from China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8

Appearance
White Powder
CAS
134523-03-8
Mf
C66h68caf2n4o10
MW
1155.36
Grade
Medicine Grade
Trademark
WHOK
Transport Package
Discreet and Disguised
Specification
As your request
Origin
China
HS Code
3001200020
Appearance
White Powder
CAS
134523-03-8
Mf
C66h68caf2n4o10
MW
1155.36
Grade
Medicine Grade
Trademark
WHOK
Transport Package
Discreet and Disguised
Specification
As your request
Origin
China
HS Code
3001200020

Product Description

Product Name: Atorvastatin calcium
Synonyms: LIPITOR;ATORVASTATIN CALCIUM SALT;ATORVASTATIN CALCIUM;ATORVASTATIN CA;[r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid calcium salt;(3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-(PHENYLCARBAMOYL)-1H-PYRROL-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID CALCIUM;(3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-;(R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium
CAS: 134523-03-8
MF: C66H68CaF2N4O10
MW: 1155.36
EINECS: 200-659-6
Melting point: 176-178°C
Storage temp.: Store at +4°C
Appearance: White Crystalline Powder

Product Introduction

Lipitor was launched in Canada, the Netherlands, the UK and the US as an orally-active hypocholesterolemic agent. It was the first pharmaceutical product ever to attain over one billion dollars in sales in its first year. It can be synthesized by a number of routes but the most efficient involves the Paal-Knorr reaction of an acetonide protected dihydroxy amino ester and a diaryl phenylacetamide diketone. Lipitor is a liver selective, reversible competitive inhibitor of HMG-CoA reductase, the rate limiting step in cholesterol biosynthesis. Lipitor monotherapy resulted in a reduction of LDL cholesterol by up to 60%. Lipitor is about 2-4 times more potent, on a dosage basis, than Simvastatin. The superior properties of Lipitor can be attributed to its greater uptake and longer duration of action in the liver. In addition to its effects on cholesterol, Lipitor is also effective in lowering triglycerides. While the mechanism is not clear, two theories proposed are: a) the decrease in cholesterol causes a concomitant increase in hepatic LDL-receptor activity (mostly B and E type) which results in a decrease in triglycerides through an increase in binding of triglycerides to VLDL and LDL, and b) the decreased level of cholesterol impairs VLDL transport of triglycerides.

Product Usage

1.Atorvastatin Calcium can cure rise of total cholesterol, low density lipoprotein cholesterol, apolipoprotein B and triglycerides.

2.Atorvastatin calcium For patients with primary hypercholesterolemia, including familial hypercholesterolemia (heterozygous type) or mixed hyperlipidemia patients , if the diet therapy and other non-drug therapy efficacy are not satisfied, it can be used this product.

COA

ItemsStandard
CharacterA white or almost white crystalline powder
IdentificationA:IR.
B:CALCIUM
water3.5~5.5
Ca%3.0~3.6
Heavy Metals (ppm)≤20
Impurity E≤0.3%
Impurity
(HPLC)
 
Impurity A≤0.3%
 Impurity B≤0.3%
 Impurity C≤0.3%
 Impurity D≤0.1%
 Other individual unknown Impurity%≤0.1%
 Total impurity≤1.0%
Assay%98.0~102.0

Tags

Atorvastatin Calcium Powder,Atorvastatin Calcium Raw Powder,Atorvastatin Calcium Dosage,Atorvastatin Calcium Usage,Atorvastatin Calcium Manufacturer,Atorvastatin Calcium Injection,Atorvastatin Calcium Supplier

Our Market

China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8

Shipment Way

China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8

Our Advantages

China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8