99% Raw Powder Vildagliptin with CAS 274901 -16-5

China 99% Raw Powder Vildagliptin with CAS 274901-16-5, Find details about China Vildagliptin, 274901-16-5 from 99% Raw Powder Vildagliptin with CAS 274901-16-5

Basic Info.

Model NO.

Vildagliptin

Usage

Pharm

Raw Material

274901-16-5

Transport Machine

Ordinary Goods Truck

Appearance

White Powder

Trademark

Recedar

Transport Package

Drum

Specification

99%

Origin

China

HS Code

0000

Model NO.

Vildagliptin

Usage

Pharm

Raw Material

274901-16-5

Transport Machine

Ordinary Goods Truck

Appearance

White Powder

Trademark

Recedar

Transport Package

Drum

Specification

99%

Origin

China

HS Code

0000

Product Desciption

99% raw powder Vildagliptin with CAS 274901-16-5

Product Name: Vildagliptin
CAS: 274901-16-5
MF: C16H15F6N5O?H3O4P?H2O
MW: 303.4
EINECS: 630-410-0
Melting point 153-155?C
alpha -78.3° (c = 9.73 in methanol)
Boiling point 531.3±50.0 °C(Predicted)
density 1.27
Fp 275.1ºC
HS Code 29339900
Uses The major metabolite of Vildagliptin
Uses Labelled Vildagliptin. It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic.

Vildagliptin, a DPP-4 inhibitor, was launched for the oral treatment of type 2 diabetes. Vildagliptin is the second DPP-4 inhibitor to reach the market behind sitagliptin, which was introduced in 2006. DPP-4 inhibitors act by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase the synthesis and release of insuli from pancreatic βcells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic α cells, which leads to reduced hepatic glucose production. However, although GLP-1 and GIP effectively lower blood glucose, they are short-lived as a result of rapid inactivation by the ubiquitous serine protease DPP-4. By inhibiting DPP-4, vildagliptin increases the concentration and duration of active incretin levels, which in turn results in increased insuli release and decreased glucagon levels in a glucose-dependent manner. Both vildagliptin and sitagliptin are potent, competitive, reversible inhibitors of DPP- 4 (IC50=3.5 and 18 nM, respectively), and they both show slow, tight-binding inhibition kinetics.

Package	carton drum with two plastic bags inside
Net weight	25KG/Drum
Storage	Sealed in cool and dry place to avoid moisture and light
Shelf life	2 years when properly stored
Lead time	1~3 days after confirmation