High Purity 99% Price Quality CAS 206361-99-1 Darunavir
China High Purity 99% Price Quality CAS 206361-99-1 Darunavir, Find details about China Darunavir, Darunavir Powder from High Purity 99% Price Quality CAS 206361-99-1 Darunavir
Basic Info.
Model NO.
BLOOM TECH Active pharmaceutical ingredient
Store Temperature
2-8 Degree
Store pH
8-9
Trademark
BLOOM TECH
Transport Package
Enterprise Standard or Customization
Specification
White powder/Water soluable
Origin
China
HS Code
2934999099
Model NO.
BLOOM TECH Active pharmaceutical ingredient
Store Temperature
2-8 Degree
Store pH
8-9
Trademark
BLOOM TECH
Transport Package
Enterprise Standard or Customization
Specification
White powder/Water soluable
Origin
China
HS Code
2934999099
Product Desciption
High Purity 99% Price Quality CAS 206361-99-1 Darunavir
What is Darunavir ?
Darunavir is the latest weapon in the arsenal of agents to combat human immunodeficiency virus type 1(HIV-1).
As an HIV-1 protease inhibitor, its mechanism of action involves blocking the cleavage of the gag and gag-pol polyproteins into functional proteins essential for the production of infectious progeny virus;
the result is the production of immature, noninfectious viral particles.
Compared to predecessor HIV protease inhibitors, darunavir retains activity against resistant stains, a critical factor with the continual emergence of multidrug- resistant (MDR) mutants. Despite experiencing a 13-fold reduction in binding to MDR HIV-1 protease, this binding is 1.5 orders of magnitude tighter than the first-generation protease inhibitors.
Function of Darunavir
Darunavir exhibits less than a 10-fold decrease in susceptibility in cell culture against 90% of 3309 clinical isolatesresistant to amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, and tipranavir.In contrast, darunavir-resistant viruses display limited susceptibility to only tipranavir, suggesting limited cross-resistance between these two protease inhibitors.To avoid the issues of the peptide-based protease inhibitors, darunavir has evolved from a structure-based design effort to minimize peptidic features and reduce molecular weight and complexity.
Application of darunavir
Treatment of HIV infection (in combination with other antiretroviral drugs)Darunavir is less affected than other protease inhibitors by mutations to resistance, but subgroups with more than 10 cumulative mutations show a >10-fold (median value) decrease in susceptibility. The major resistance mutations occur at positions 50 (150V), 54 (I50M/L), 76 (L76V) and 84 (I84V) of the protease gene.
| Product name | Darunavir |
| Appearance | white powder |
| Assay | 99% |
| CAS | 206361-99-1 |
| Shelf Life | 24 months when properly stored |
| Storage | Cool Dry Place |
Darunavir is the latest weapon in the arsenal of agents to combat human immunodeficiency virus type 1(HIV-1).
As an HIV-1 protease inhibitor, its mechanism of action involves blocking the cleavage of the gag and gag-pol polyproteins into functional proteins essential for the production of infectious progeny virus;
the result is the production of immature, noninfectious viral particles.
Compared to predecessor HIV protease inhibitors, darunavir retains activity against resistant stains, a critical factor with the continual emergence of multidrug- resistant (MDR) mutants. Despite experiencing a 13-fold reduction in binding to MDR HIV-1 protease, this binding is 1.5 orders of magnitude tighter than the first-generation protease inhibitors.
Function of Darunavir
Darunavir exhibits less than a 10-fold decrease in susceptibility in cell culture against 90% of 3309 clinical isolatesresistant to amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, and tipranavir.In contrast, darunavir-resistant viruses display limited susceptibility to only tipranavir, suggesting limited cross-resistance between these two protease inhibitors.To avoid the issues of the peptide-based protease inhibitors, darunavir has evolved from a structure-based design effort to minimize peptidic features and reduce molecular weight and complexity.
Application of darunavir
Treatment of HIV infection (in combination with other antiretroviral drugs)Darunavir is less affected than other protease inhibitors by mutations to resistance, but subgroups with more than 10 cumulative mutations show a >10-fold (median value) decrease in susceptibility. The major resistance mutations occur at positions 50 (150V), 54 (I50M/L), 76 (L76V) and 84 (I84V) of the protease gene.
WHO WE ARE
1.We Focus on the technology of Organic Synthesis since 2008.
2.API/Pharmaceutical intermediate/Fine chemical/New material/Extraction etc.
3.Chemical reagent: Over 250,000 categories in stock, achieve your R&D goal rapidly.
4.Customization/Technology support/R&D assistance/CRO/CMO/ODM.
5.We have the complete ISO system to make your purchasing risk into the lowest.
GB/T19001-2016/ISO9001:2015
GB/T24001-2016/ISO14001:2015
GB/T28001-2011/OHSAS18001:2007
Q1: Are you a manufacturer?
Yes, BLOOM TECH have concentrated on Organic synthesis over 12 years since 2008.
Advanced R&D technology, 250,000 categories chemical reagent are in stock.
Trading products we will serve for you with our ISO supplier system, making your purchasing risk into the lowest.
In addition, we provide the customization service of a new compound from lab to bulk manufacturing.
Q2: How to contact with us?
You can contact with us on Made-in-China, the Average Response Time is 0-4h on Work time, <24h on Non-work time.
For every inquiry, our sales will provide the one-for-one service for you.
Q3:Which kind of payment do you accept?
Normal orders: Company account(The price will be 5%-13% extra discount)
Sample/small orders: Paypal(The 5-10% extra fee),Western Union etc.
About the payment term, we will negotiate alone.
Q4:How to confirm the Product Quality before placing orders?
1st, you can get free samples for some products, just pay the basic cost for us.
2nd,Also you can send the specification or your quest to us, we will customize the products for you.
3rd,We emphasis that our whole company make a living with organic chemical and customers, we absolutely impossible to sale any fake goods, unqualified goods, it is shame! And None False certificate/lie/illegal thing in our sales net!
Q5:How do you treat quality complaint?
The customer complaint handling procedures is the key part in Our ISO management system. We will set up an investigation team for your complaint, and give the handling plan and our corrective and preventive measures within a limited time.
Q6:Package
We will refer the MSDS to design the package standard and show you at the PI or Quotation list.
If you want customize package and haven't go against the principle of science, we will do as your request. The cost will be calculate your request.
For dangerous goods, only one style of package, we will do as the UN standard.
Q7:Shipping
We have R&D and manufactured chemicals for 12 years, we have rich experience on Shipping, Many famous companies cooperated with us stably, we are good at shipping all kinds of chemicals.
General goods: The best service, price and lead time.
Dangerous goods: The professional cooperated company, the details please check our website.
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