Darunavir Ethanolate Darunavir Material Pharmaceutical Grade Darunavir
China Darunavir Ethanolate Darunavir Material Pharmaceutical Grade Darunavir, Find details about China Darunavir, Darunavir Ethanolate from Darunavir Ethanolate Darunavir Material Pharmaceutical Grade Darunavir
Basic Info.
Model NO.
Condavo-Darunavir
Name
Darunavir
Product Name
Darunavir Powder
Appearance
White Powder
Test Method
HPLC UV
Storage
Cool Dry Place
Assay
99%
Grade
Pharmaceutical Grade
COA
Available
Mf
C27h37n3o7s
CAS
206361-99-1
Psa
148.80000
Logp
4.42820
Density
1.34G/Cm3
Flash Point
74-76c
Refractive Index
1.62
Trademark
Condavo
Transport Package
1kg/ Aluminium Bag or 25kg/Drum; as Required
Specification
99%
Origin
Shaanxi
Model NO.
Condavo-Darunavir
Name
Darunavir
Product Name
Darunavir Powder
Appearance
White Powder
Test Method
HPLC UV
Storage
Cool Dry Place
Assay
99%
Grade
Pharmaceutical Grade
COA
Available
Mf
C27h37n3o7s
CAS
206361-99-1
Psa
148.80000
Logp
4.42820
Density
1.34G/Cm3
Flash Point
74-76c
Refractive Index
1.62
Trademark
Condavo
Transport Package
1kg/ Aluminium Bag or 25kg/Drum; as Required
Specification
99%
Origin
Shaanxi
Product Desciption
Darunavir Ethanolate Darunavir Material Pharmaceutical Grade Darunavir
| Product name | Darunavir |
| Appearance | white powder |
| Assay | 99% |
| CAS | 206361-99-1 |
| Shelf Life | 24 months when properly stored |
| Storage | Cool Dry Place |
As an HIV-1 protease inhibitor, its mechanism of action involves blocking the cleavage of the gag and gag-pol polyproteins into functional proteins essential for the production of infectious progeny virus;
Darunavir exhibits less than a 10-fold decrease in susceptibility in cell culture against 90% of 3309 clinical isolatesresistant to amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, and tipranavir.In contrast, darunavir-resistant viruses display limited susceptibility to only tipranavir, suggesting limited cross-resistance between these two protease inhibitors.To avoid the issues of the peptide-based protease inhibitors, darunavir has evolved from a structure-based design effort to minimize peptidic features and reduce molecular weight and complexity.
Treatment of HIV infection (in combination with other antiretroviral drugs)Darunavir is less affected than other protease inhibitors by mutations to resistance, but subgroups with more than 10 cumulative mutations show a >10-fold (median value) decrease in susceptibility. The major resistance mutations occur at positions 50 (150V), 54 (I50M/L), 76 (L76V) and 84 (I84V) of the protease gene.
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