Manufacturer Supply Chemical/Pharmaceutical Grade Clevidipine Butyrate CAS 167221 -71-8

China Manufacturer Supply Chemical/Pharmaceutical Grade Clevidipine Butyrate CAS 167221-71-8, Find details about China Cleviprex, Clevidipine from Manufacturer Supply Chemical/Pharmaceutical Grade Clevidipine Butyrate CAS 167221-71-8

Basic Info.

Model NO.

R-60

Common Name

Clevidipine

CAS Number

167221-71-8

Molecular Weight

456.316

Density

1.3±0.1 g/cm3

Boiling Point

539.7±50.0 °c at 760 Mmhg

Molecular Formula

C21h23cl2no6

Melting Point

128-130°c

Flash Point

280.2±30.1 °c

Transport Package

Bag, Drum

Origin

China

HS Code

29339900

Model NO.

R-60

Common Name

Clevidipine

CAS Number

167221-71-8

Molecular Weight

456.316

Density

1.3±0.1 g/cm3

Boiling Point

539.7±50.0 °c at 760 Mmhg

Molecular Formula

C21h23cl2no6

Melting Point

128-130°c

Flash Point

280.2±30.1 °c

Transport Package

Bag, Drum

Origin

China

HS Code

29339900

Product Desciption

Product Description:
Product Name: Clevidipine butyrate CAS NO: 167221-71-8

Synonyms:
5-O-(butanoyloxymethyl)3-O-methyl4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;
Cleviprex;
Clevidipine butyrate;

Chemical & Physical Properties:
Appearance: Powder
Assay :≥99.00%
Density: 1.289g/cm3
Boiling Point: 539.7ºC at 760mmHg
Flash Point: 280.2ºC
Melting Point: 128-130ºC
Storage Temp.: Refrigerator
Vapor Pressure: 0.0±1.4 mmHg at 25ºC
Index of Refraction: 1.543

Safety Information:
Safety Statements: S24/25
HS Code: 29339900

Calcium channel blocker, used as an oral antihypertensive.
Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.IC50 Value: 7.1 nM at V(H) = -40 mV Target: calcium channelin vitro: Both clevidipine and nitroglycerin completely reversed U46619-induced contraction (clevidipine (50% effective concentration [EC50] = 3.88 +/- 0.84 x 10(-6) mol/L, nitroglycerin EC50 = 4.84 +/- 2.76 x 10(-8) mol/L) . A decrease in temperature increased the half-life of clevidipine in blood, whereas dilution of the blood did not affect the in vitro half-life of clevidipine. The albumin concentration affected the hydrolysis rate of clevidipine in RBC suspended with saline .in vivo: Clevidipine is a high-clearance drug with a relatively small volume of distribution, resulting in an extremely short half-life in all species studied. The median initial half-life of the individual value (Bayesian estimates) is 12, 20, and 22 s in the rabbit, rat, and dog, respectively. The extremely high clearance value and the small volume of distribution resulted in short half-lives of clevidipine, 2.2 and 16.8 min, respectively. The blood concentration and dose rate producing half the maximal effect (i.e. EC50 and ED50) were approximately 25 nM and 1.5 microg/kg/min, respectively.Clinical trial: CARVE: Clevidipine for Vasoreactivity Evaluation of the Pulmonary Arterial Bed. Phase 4

If you are interested in our products or have any questions, please feel free to contact us!

Quality Assurance:
COA will be provided before making payment.
Product standards strictly complies to COA.
If any quality problem verified , 100% replace product or return payment.
If still feel worried, sample can be provided.

FAQ:

Q1. What's the MOQ?
A: It is based on the different product. Some are 1g and some are 1 ton. Plesae be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FeDex will be 10 days to you.
Q3. If I need less than the MOQ, is it possible.
A: Yes. If less than MOQ. the price will be 5% more than the MOQ. It based on the different product. Plesae be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. It based on the different product. Plesae be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers.The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, west union, money gram, order online.

Our services:
1) One to one business communication.
2) Any inquiries will be replied within 12 hours.
3) We offer convenient one-station purchasing service.Our professionaland thoughtful after-sales service eliminates your worries.
4) We has 10 years' exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.
5) OEM/ODM Available.
6) Reasonable & competitive price, fast lead time.
7) Sample is available for your evaluation & Formulation development.
8) Faster delivery: Sample order in stock and 3-5 workdays for bulk production.
9) Excellent after-sale service.

Packaging & Delivery:

Packing :	1kg/bag ,25kg/bag;25kg/drum; according to your requirements

Port:	Shanghai/Tianjin/Dalian/Beijing/Xi'an
Lead Time :	3-5 working days upon received the payment
For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea.