We are the most professional real "MANUFACTURER" and "SUPPLIER" of TRANEXAMIC ACID on MIC, welcome the enquiry from both Foreign and Domestic customers.

We can provide:

(1) Cholic Acid (Free Grade 50%)                                                             CAS #:81-25-94

(2) Cholic Acid (Food Grade 90%)                                                            CAS #:81-25-94

(3) Cholic Acid (Pharmaceutical Grade 95%;98%)                                CAS #:81-25-94

(4) Chenodeoxycholic Acid(intermediate of Ursodeoxycholic Acid)      CAS #:474-25-9

(5) 3alpha-Hydroxy-7-oxo-5beta-cholic acid(7K-LCA)                           CAS #:4651-67-6

(6) Ursodeoxycholic Acid(EP9/USP/IP GRADE WITH GMP)               CAS #:128-13-2  

(7)Tauroursodeoxycholic acid   EP9                                                           CAS #:14605-22-2
(8)Obeticholic Acid  (OBCA)  98%/99%                                                   CAS #:459789-99-2
(9)Obeticholic Acid Intermediate-1(OB N-1)                                            CAS #:915038-26-5
(10)Obeticholic Acid Intermediate-2(OB N-2)                                          CAS #:1516887-33-4
(11)Obeticholic Acid Intermediate-3(OB M-2)                                          CAS#:1352328-66-5
 

Description:

Product Name:TRANEXAMIC ACID

CAS:1197-18-8
Molecular Formula: C₈H₁₅N02
Molecular Mass:157.21
[Appearance]: white crystal powder, no foreign substance, no obvious odor
[Melting Point]:300ºC
[Loss on Dry]: ≤1.0%
[Residue on Ignition]: ≤0.1%
[Heavy Metal ]: ≤10ppm
[Assay Determination]: 98.0%~101.0% (dries basis)
[Related Substance]:the single impurity≤0.1%, total impurities≤2.0%
[Package and Storage Condition]: 25kg/drum, store and seal away from light
 

Summary
Tranexamic acid is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders.

Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.

Pharmacodynamics
Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin.At much higher concentrations it behaves as a noncompetitive inhibitor of plasmin similar to aminocaproic acid, a similar antifibrinolytic which is 10-fold less potent. Tranexamic acid binds more strongly than aminocaproic acid to both the strong and weak receptor sites of the plasminogen molecule in a ratio corresponding to the difference in potency between the compounds. In patients with hereditary angioedema, inhibition of the formation and activity of plasmin by tranexamic acid may prevent attacks of angioedema by decreasing plasmin-induced activation of the first complement protein (C1).
Off-target antagonism of GABA(A) receptors may be associated with the development of convulsions and hyperexcitability following tranexamic acid administration - the risk appears higher with improper administration or administration during cardiovascular surgery. Consider EEG monitoring of patients with a history of seizure

Mechanism of action
Tranexamic acid competitively and reversibly inhibits the activation of plasminogen via binding at several distinct sites, including four or five low-affinity sites and one high-affinity site, the latter of which is involved in its binding to fibrin. The binding of plasminogen to fibrin induces fibrinolysis - by occupying the necessary binding sites tranexamic acid prevents this dissolution of fibrin, thereby stabilizing the clot and preventing hemorrhage.
Absorption
The bioavailability of tranexamic acid after oral administration in humans is approximately 30 to 50% of the ingested dose and is not affected by food intake. The Cmax and Tmax following multiple oral doses (1300 mg three times daily x 5 days) were 16.41 mcg/mL and 2.5 h, respectively
 

QINGDAO HAOSAIL COA OF TRANEXAMIC ACID BP




QINGDAO HAOSAIL  INVESTED CHOLIC ACID SERIES MANUFACTURER GMP CERTICIFICATION

QINGDAO HAOSAIL PLANT

QINGDAO HAOSAIL WORKSHOP

QINGDAO HAOSAIL LAB

QINGDAO HAOSAIL WAREHOUSE


Qingdao Haosail Science Co., Ltd is a joint stock company, stock No. is 839542. We are manufacturer and globalsupplier of Spirulina,Chlorella, Spirulina blue(phycocyanin) and nutritional ingredients, and also a flexible and leading contract manufacturer of nutritional and dietary supplements, our products include powders, diversified tablets, hardgel capsules and softgel capsules, in bulk packaging and all kinds of retail packaging.

Also, based on our professional experience and capability of sourcing and purchasing diverse nutritional ingredients in China, we also provide our customers with a full range of raw materials which are used in Nutritional and Dietary industry. Our people are proficient in the knowledge and specialty of nutritional ingredients, so we are confident that we are able to offer the right and best ingredients to you. Moreover, benefit from our strategic partnership with many key manufacturers of nutritional ingredients, as well as our collective purchasing, we are able to offer very competitive price to you.

Our people is dedicated to supply nutritional and dietary products according to customers' requirements with consistently high quality and considerate service.

WELCOME To CONTACT US!

QINGDAO HAOSAIL COMPANY TEAM BUILDING


QINGDAO HAOSAIL EXIHIBITION


QINGDAO HAOSAIL PACKAGE