CAS 138112-76-2 Raw Powder Agomelatine

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Product Name	AGOMELATINE
Cas No.	138112-76-2	Delivery time	7-10 days
EINECS  No.	629-727-7	Storage	-20 degrees Celsius
Appearance	white powder	MW	243.3
Shelf  life	2 years	MF	C15H17NO2

Agomelatine is the world's first melatonin receptor MT1 and MT2 agonist antidepressant. It was developed by the French company Servier and is suitable for the treatment of severe depressive episodes in adult patients. We know that melatonin is an endogenous neurohormone, which is secreted only by the anterior pituitary of the pineal gland at night and acts on the melatonin receptors concentrated in the suprachiasmatic nucleus (SCN) of the hypothalamus. Participates in mediating the circadian rhythm of mammals. It is a well-known guardian of time in the body and corrects the biological clock regulated by the external circadian cycle. However, due to the high catabolism rate of melatonin in the body, its short half-life and poor selectivity for its receptor located in the SCN have limited its use in the treatment of circadian circadian rhythm disorders. Therefore, in order to overcome these shortcomings of melatonin, the researchers designed a series of melatonin analogs. Molecular model studies show that the indole ring of melatonin is the structural site for catabolism inactivation, so the indole ring becomes an ideal site for isosteric modification. The agomelatine developed by Servier is a biological (electronic) isostere analog of melatonin. It replaces the indole ring with a nucleus, making it more metabolically stable than melatonin.


 

 

 

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Hongkong XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many other countries.

1. Quality. Every batch of steroid powders has to be tested by our QC(quality control) before they are allowed to sell.

2. Delivery We have stock, so we can deliver quickly on the very day when receive the payment. Within 24 hours after receiving the payment Lead time is 4 or 7 days.

3. Discreet package Safely and Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids-related name will appear on the parcels. high successful delivery rate

4. Warm after-sale service Any of your questions would be solved for the first as soon as possible.

CAS 138112-76-2 Raw Powder Agomelatine