Application
    The listing of Agomelatine is a new breakthrough in the field of depression treatment. It is both a melatonin MT1/MT2 receptor agonist and a 5-ht2C receptor antagonist. Through the synergistic action of the two, the disorder of biological rhythm of patients with depression can be restored to normal, and the antidepressant effect can be produced. Its unique mechanism of action opens up an innovative way for the treatment of depression. The mechanism of action of agomelatine is completely different from that of currently commonly used antidepressants such as selective serotonin reuptake inhibitors (SSRIS) and serotonin-norepinephrine reuptake inhibitors (SNRI) : SSRI and SNRI antidepressants work by increasing serotonin levels, but this has been associated with many side effects, such as weight change, sexual dysfunction, withdrawal syndrome, etc. The drug molecular structure of agomelatine directly binds to the 5-ht2C receptor in the postsynaptic membrane, thereby delivering its antidepressant effects without increasing the 5-HT2C concentration in the synaptic cleft. This unique mechanism of action enables agomelatine to exert its antidepressant effect quickly and effectively, while avoiding the occurrence of drug side effects to the maximum extent.

      Another unique target of Agomelatin is the melatonin receptor. MT1 MT2 receptors are densely distributed in the human suprachiasmatic nucleus, which controls sleep rhythms. By activating the MT1 MT2 receptor, agomelatine significantly improved sleep quality and daytime arousal. The quality of sleep state and the outcome of depression has a mutual causal relationship. It is reported that 80% of people with depression have some degree of sleep disturbance. The improvement of sleep quality directly promotes the improvement of the overall clinical condition of patients with depression.
 

Packing and Storage: Packed in double plastic bags inside, outside with 25kg Fiber Drum.

Drum Size: 40cm*40cm*50mm, 25KG/drum Nt.;27.5Kg/drum.Gt. Store in a well-closed container away from moisture.

Shelf Life: 2 years if sealed and store away from direct sun light.

Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat

Delivery time: Around 3-5 workdays after your payment.