Weight Management Powder Oleoylethanolamide /Oea CAS 111-58-0
China Weight Management Powder Oleoylethanolamide /Oea CAS 111-58-0, Find details about China Oleoylethanolamide, N Oleoylethanolamide from Weight Management Powder Oleoylethanolamide /Oea CAS 111-58-0
Basic Info.
Model NO.
SWY-Oleoylethanolamide
Colour
White
Product Name
Oleoylethanolamide
Storage
Keep Dry and Away From Light.
Shipping
FedEx, DHL, EMS, TNT, 4px, Royal Postal, Aramex
Trademark
SWY
Transport Package
Aluminum Foil Bag Carton
Specification
1KG/Bag or others package
Origin
China
Model NO.
SWY-Oleoylethanolamide
Colour
White
Product Name
Oleoylethanolamide
Storage
Keep Dry and Away From Light.
Shipping
FedEx, DHL, EMS, TNT, 4px, Royal Postal, Aramex
Trademark
SWY
Transport Package
Aluminum Foil Bag Carton
Specification
1KG/Bag or others package
Origin
China
Product Desciption
Oleoylethanolamide (OEA), an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells.
Oleoylethanolamide suppresses TGF-β1 induced hepatic stellate cells (HSCs) activation in vitro via PPAR-α. To assess the impact of Oleoylethanolamide on HSCs activation, the expression levels of α-SMA and Col1a in TGF-β1-stimulated HSCs are examined by qPCR.
The mRNA levels of α-SMA and Col1a are markedly induced in the group of CFSC cells with TGF-β1 (5 ng/mL) stimulation for 48h, while the mRNA levels are suppressed when treated with Oleoylethanolamide in a dose-dependent manner. Immunofluorescence and western blot results show that Oleoylethanolamide treatment dose-dependently inhibits the protein expression of α-SMA, the marker of HSC activation. The inhibitory effects of Oleoylethanolamide on HSCs activation are completely blocked by PPAR-α antagonist MK886 (10 μM). Moreover, the mRNA and protein expression levels of PPAR-α are down-regulated with TGF-β1 stimulation, while
Oleoylethanolamide treatment restores these changes in dose-dependent manner. In addition, the phosphorylation of Smad 2/3 is upregulated in the presence of TGF-β1 stimulation, consistent with the observed effects on HSC activation, while Oleoylethanolamide (10 μM) reduces the phosphorylation of Smad2/3 in CFSC simulated with TGF-β1
Oleoylethanolamide suppresses TGF-β1 induced hepatic stellate cells (HSCs) activation in vitro via PPAR-α. To assess the impact of Oleoylethanolamide on HSCs activation, the expression levels of α-SMA and Col1a in TGF-β1-stimulated HSCs are examined by qPCR.
The mRNA levels of α-SMA and Col1a are markedly induced in the group of CFSC cells with TGF-β1 (5 ng/mL) stimulation for 48h, while the mRNA levels are suppressed when treated with Oleoylethanolamide in a dose-dependent manner. Immunofluorescence and western blot results show that Oleoylethanolamide treatment dose-dependently inhibits the protein expression of α-SMA, the marker of HSC activation. The inhibitory effects of Oleoylethanolamide on HSCs activation are completely blocked by PPAR-α antagonist MK886 (10 μM). Moreover, the mRNA and protein expression levels of PPAR-α are down-regulated with TGF-β1 stimulation, while
Oleoylethanolamide treatment restores these changes in dose-dependent manner. In addition, the phosphorylation of Smad 2/3 is upregulated in the presence of TGF-β1 stimulation, consistent with the observed effects on HSC activation, while Oleoylethanolamide (10 μM) reduces the phosphorylation of Smad2/3 in CFSC simulated with TGF-β1
OLEOYLETHANOLAMIDE (OEA) Powder CAS 111-58-0 Benefits Oleoylethanolamide (OEA) is a natural metabolite that is made in small amounts in your small intestine. OEA helps regulate hunger, weight, body fat and cholesterol by binding to a receptor known as PPAR-Alpha (Peroxisome proliferator-activated receptor alpha). In essence, OEA increases the metabolism of body fat and tells your brain that you are full and it's time to stop eating. OEA is also known to increase non-exercise related calorie expenditure.
OLEOYLETHANOLAMIDE (OEA) Powder CAS 111-58-0 Application
Oleoylethanolamide (OEA) works to activate something called PPAR and simultaneously ramps up fat-burning and decreases fat storage. When you eat, OEA levels increase and your appetite decreases when the sensory nerves that link to your brain tell it that you're full. PPAR-α is a group of ligand-activated nuclear receptor that involved in the gene expression of lipid metabolism and energyhomeostasis
You Might Also Like
30-50cbm Movable Hopper for Discharging Bulk Cargo
4b-Wd Bsp Male ED Sealing Plug
Standard Specimen Clamp for Microtome
Luxury Crystal Glass Scent 30ml 1 Oz Perfume Bottle
Tetra Pak Sugar Dissolving System
High Quality Factory Supply Zinc Plated Pozi Countersunk Chi......
Improve Root System Root Promoter Seaweed Functional Organic......
Creative Handmade Three-Dimensional Photo Frame Outside Thic......
Jinko Panel High Quality Pmw Dimming Controller Ni-MH Batter......
80/20 Copper Nickel ( CuNi20 )
Natural Blue Gemstone Stone Oval Vanity Hotel Wash Basin Sin......