Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery

China Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery, Find details about China Azd 3759, CAS 1626387-80-1 from Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery

Model NO.
AZD 3759
Product Name
Azd 3759
Apearance
White Powder
CAS
1626387-80-1
Mf
C22h23clfn5o3
MW
459.9
Storage
Cool Dry Place
Shelf Life
2 Years
Deliver Time
7-10days
Trademark
BIOCAR
Transport Package
Bag or Drum
Specification
1kg/bag- 25kg/drum
Origin
China
HS Code
00000000
Model NO.
AZD 3759
Product Name
Azd 3759
Apearance
White Powder
CAS
1626387-80-1
Mf
C22h23clfn5o3
MW
459.9
Storage
Cool Dry Place
Shelf Life
2 Years
Deliver Time
7-10days
Trademark
BIOCAR
Transport Package
Bag or Drum
Specification
1kg/bag- 25kg/drum
Origin
China
HS Code
00000000
Factory Supply Hot Sale AZD 3759 CAS 1626387-80-1 with Safe Delivery
Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery
 
Basic Information
Product Name
 
AZD 3759

Mini Order:
 
1g

Purity:
 
>99%

Payment ways:
 
Bank Transfer, Western Union, Money Gram and Bitcoin

Delivery ways:
 
All Express Modes(EMS, DHL, TNT, FedEx, UPS,TOll etc.) Bulk by sea or air.

Shipping address:
 
Provide your Valid and Correct destination address info with post code, phone number.

Packing:
 
Select best ways according to quantity and safety degree,professional and experienced.

Lead time:
 
Within 12 hours upon receipt of payment

Tracking number:
 
Offered once it is released

Shipping time:
 
3-7 working days (Door-to-Door)

After-sale service:
 
24/7 Online for any problems
 
 
Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery
 


Description

AZD3759 is an extremely effective drug with 100% intracranial permeability, far exceeding erlotinib, Gefitinib, afatinib and Oxitinib. Patients with brain metastases from non-small cell lung cancer (NSCLC) have neurological impairments: slowness, dementia, seizures, dyskinesia, etc. Accompanied by a significant reduction in quality of life, a very poor prognosis, and a lack of very effective treatment. One reason for this is the "blood-brain barrier," which prevents harmful substances in the blood from seeping chemicalbooks into the brain and limits the ability of drugs to reach the brain. Another is that it is insensitive to some antitumor drugs that can penetrate the brain. Therefore, previous surgery and radiotherapy are the main treatment methods for BMS. Radiotherapy can effectively control the progression of BMS, but has limited effect on prolongs the survival time. In recent years, the rapid development of molecular targeting, anti-angiogenic therapy, immunosuppressive drugs and other drugs have provided more treatments for lung cancer brain metastases, and improved the survival of such patients.

 
 
Function
AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3nM, 0.2nM, and 0.2nM for EGFR(WT), EGFR(L858R), and EGFR(exon19Del), respectively. AZD3759 inhibited EGFR phosphorylation with IC50 of 7.2nM. AZD3759 inhibited the proliferation of pEGFR pathway and EGFR mutation-derived cells PC-9 and H3255 with IC50 of 7Chemicalbook.7nM and 7nM, respectively, and did not inhibit the proliferation of H838 cells. Phase I clinical trials of AZD3759 showed very good control activity of intracranial lesions, and dosages of 200mg or 300mg twice daily were recommended. AZD3759 did not perform better than other EGFR-targeting agents in the control of extracranial lesions, but showed a greater advantage in the control activity of intracranial lesions. Patients with meningeal metastases in this clinical trial benefited from AZD3759, and the 300mg dose appeared to achieve greater control rates.

 

 

Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery

 

Application
AZD3759 is a potent EGFR inhibitor permeable to the central nervous system. The IC50 of EGFRwt, EGFRL858R and EGFRexon 19Del were 0.3, 0.2 and 0.2 nM, respectively.
 

Product Picture and Package

Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery
Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery
Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery

Related Product
Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe DeliveryFactory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery

Our Company

Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe DeliveryGuangzhou Biocar Biotechnology Co.,Ltd.,formerly known as Guangdong Yangye Pharmaceutical Factory established in 2005, which is affiliated to Wuhan Biocar Group. With the rise of Internet +, company's business process is accelerating. The company's board of directors has decided to establish Guangzhou Yangye Biotechnology Co., Ltd. at the end of 2016.
Guangzhou Biocar Biotechnology Co.,Ltd. is located near Zhujiang New Town, Tianhe District, one of the prosperous areas in Guangzhou. This helps facilitate business negotiations at home and abroad. It is a high-tech enterprise centered in Guangdong, radiating across our country and facing the world. And it is mainly engaged in the research, development and sales of new chemical raw materials, the custom synthesis and import and export of pharmaceutical intermediates and APIs, the agency sales of pharmaceutical chemicals, the research and development, production and sales of flavors, fragrances and chemical raw materials. Its factory covers an area of more than 4,000 acres and has more than 600 employees.
Guangzhou Biocar Biotechnology has a production base for deep processing of feed additives and veterinary drug intermediates based on main pharmaceutical intermediates.
It has always adhered to the tenet of "Being faithful, cultivating harmony and achieving win-win cooperation" and treats every customer sincerely.
We are looking forward to cooperating with you sincerely, and making mutual benefit and brilliance!


Packing, Delivery and Payment
Factory Supply Hot Sale Azd 3759 CAS 1626387-80-1 with Safe Delivery

Why Choose Us?

1. High-concentration products, strictly control the quality.
2. Reasonable and flexible price matched with high quality.
3. Spot samples can be shipped quickly after payment, saving time for receiving goods.
4.Full experience of large numbers containers loading in Chinese sea port.
5. Safe raw materials from China.
6. Have professional customs clearance capabilities and the best after-sales service.


Our Service 

 1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
 2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
 3.We can send the goods to your delivery address directly. It is relatively safe and fast. 
 4.Quick and clear response to customers questions.
 5.We could make our price discount if you place a substantial order with us.
 6.Products can be packaged according to customer requirements.


F.A.Q

1:Can I get some samples before bulk order?
Most products provide free samples, but the shipping cost be paid by customers.

2: What's your MOQ?
For the high value product, our MOQ starts from 10g,100g and 1kg.

3: Which kind of payment terms do you accept?
PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union, L/C, Alibaba trade assurance, Cashapp,Moneygram or Bitcoin.

4.How to place an order?
You can contact me through Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and then we will give you a quote. If you choose one of the above payment methods, we will arrange the delivery for you.

5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

6:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.