High Purity Synthetic Anticancer Peptide Pnc27 Pnc 27 Cosmetic Pnc-27
China High Purity Synthetic Anticancer Peptide Pnc27 Pnc 27 Cosmetic Pnc-27, Find details about China Nutrition Supplements, Health Care from High Purity Synthetic Anticancer Peptide Pnc27 Pnc 27 Cosmetic Pnc-27
Basic Info.
Model NO.
DGJ256
Model NO.
DGJ256
Product Desciption
Product Description:
PNC-27 is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor
cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells.
PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence
that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in
contrast to the effects of many chemotherapeutic agents
Our service:
1. One to one business communication.
2. Any inquiries will be replied within 12 hours.
3. We offer convenient one-station purchasing service. Our professionaland thoughtful after-sales service eliminates your worries.
4. Strictly on selecting raw materials.
5. Reasonable & competitive price, fast lead time.
FAQ:
Q1: Are you a manufacturer?
Yes, we are manufactuer.
Q2: Which kind of payment terms do you accept?
For small order, you can pay by T/T, Western Union, nomal order by T/T to our company account.
Q3: Can you give me a discount price?
Surely, It depend on your qty.
Name | PNC-27 |
Source | synthetic |
Appearance | White Powder |
Purity | 98% |
Molecular Formula | C84H128N18O24 |
Packing | According to clients's requirements |
PNC-27 is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor
cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells.
PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence
that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in
contrast to the effects of many chemotherapeutic agents
Package & Shipping
Our service:
1. One to one business communication.
2. Any inquiries will be replied within 12 hours.
3. We offer convenient one-station purchasing service. Our professionaland thoughtful after-sales service eliminates your worries.
4. Strictly on selecting raw materials.
5. Reasonable & competitive price, fast lead time.
FAQ:
Q1: Are you a manufacturer?
Yes, we are manufactuer.
Q2: Which kind of payment terms do you accept?
For small order, you can pay by T/T, Western Union, nomal order by T/T to our company account.
Q3: Can you give me a discount price?
Surely, It depend on your qty.
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