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Whats-A: 0086-153=7767=2652Product details: Product Name | Noopept |
Other names | GVS-111;Nopept;Glycine, 1-(2-phenylacetyl)-L-prolyl-, ethyl ester;Ethyl 1-(phenylacetyl)-L-prolylglycinate;N-phenylacetyl-L-prolylglycine ethyl ester |
CAS NO | 157115-85-0 |
Molecular Formula | C17H22N2O4 |
Molecular Weight | 318.368 |
Appearance | White powder |
Description
Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.IC50 Value:Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM). GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action.in vivo: N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively)Toxicity: Noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity. Clinical trial: Discontinued.Packing&ShippingProduct Packing
Iron drum & plastic drum packaging
200kg/drum
850kg/drum
200kg/drum&plastic drum
180kg/drum&plastic drum
25kg/plastic drum&Cardboard bucket
Plastic bag & kraft paper bag
1200kg/bag
50kg/plastic bag
25kg/plastic bag&kraft paper bag
Shipping
Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
For mass orders, it will be delivered by air or sea.
Depending on your location, please allow 1-5 business days for your order to arrive.
For small order, please expect 3-7 days by UPS DHL EMS.
For mass order, please allow 5-8 days by Air, 15-30 days by Sea.
About Us:HUBEI AOKS BIO-TECH CO.,LTD is located in Hubei province of China.We specialized in active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drugs and agrochemicals.
We have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling.Our products are exported to more than 60 countries overseas, 80% of which are exported to Europe and America, and 20% to Southeast Asia, the Middle East, South Africa and other regions. Because of excellent quality and after-sales service, our company has gained a good reputation at home and abroad.
"Quality Best,Customer First" is what we adhering,sincerely looking forward to establish long-term and mutual beneficial business relationship with worldwide customers.
Why Choose us?
1.Control raw materials strictly,our products are the highest purity. Quality have Gurantee.
2.Reasonable and competitive price. Provide the best and professional service. Stable price have
Gurantee.
3.Fast delivery of the samples,samples from stock. Produce by our own factory, have sufficient supply. Timely have Gurantee.
4.Reliable shipping way, Full experience agent . Shipment safety have Gurantee.
5.Best after-service after shipment. After Service have Gurantee.
Our Service
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
Our Team
Certification
F.A.Q
1.Are you a manufacturer?
Yes, we are factory located in Hubei province.
2.Do you accept sample orders?
Yes,we welcome sample orders to test and check our product quality.
Your reliance is the first step of our cooperation.
3.Do you test all your goods before delivery?
Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.
4.How about the lead time?
Sample 1-2 days, mass production time needs 1-2 weeks.
If we have stock, we can ship to you the second day after we receive the payment.
5.How about the product quality?
We are the leader in the chemical area in China. We have confidence for our product quality.
For the same quality product, we have the lowest price. For the same price, we have the best quality.
6.Will your company be missing after we pay you in advance?
We do chemicals in life! We will never get missing.
7.We don't know you at all, how can we trust you?
You are always warm welcomed to visit us at any time.Before we start B2B, Made-in-China has audited our company on-spot and approved our credit.Commitment is the No.1 Point of our Enterprise's Value.
8.How do you treat quality complaint?
First of all,our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.