Nonsteroidal Estrogen Diethylstilbestrol CAS 56-53-1 Diethylstilbestrol Powder
China Nonsteroidal Estrogen Diethylstilbestrol CAS 56-53-1 Diethylstilbestrol Powder, Find details about China Diethylstilbestrol, Diethylstilbestrol Powder from Nonsteroidal Estrogen Diethylstilbestrol CAS 56-53-1 Diethylstilbestrol Powder
Product Description
| High Purity Nonsteroidal Estrogen Diethylstilbestrol CAS 56-53-1 Diethylstilbestrol Powder | |
| Product Name: | Diethylstilbestrol |
| Synonyms: | Stilboestrol; Atovaquone;DIETHYLSTILBESTROL 97% MIXTURE OF CIS&diethylstilbestrol, mixture of cis and trans;Diethylstilbestrol,mixture of cis and trans;DIETHYLSTILBESTROL, 99%, MIXTURE OF CIS AND TRANS;4,4'-Hex-3-ene-3,4-diyldiphenol;DES;Diethylstilbestrol;3,4-Bis(4-hydroxyphenyl)-3-hexene |
| CAS | 56-53-1 |
| MF: | C18H20O2 |
| MW: | 268.35 |
At first glance, it might be surprising that synthetic nonsteroidal molecules such as diethylstilbestrol (DES) could have the same activity as estradiol or other estrogens. DES can be viewed, however, as a form of estradiol with rings B and C open and a six-carbon ring D. The activity of DES analogs was explained in 1946. It was proposed that the distance between the two DES phenol OH groups was the same as the 3-OH to 17-OH distance of estradiol; therefore, they could both fit the same receptor. Medicinal chemists have shown the OH-to-OH distance to be actually 12.1 ? in DES and 10.9 ? in estradiol. In aqueous solution, however, estradiol has two water molecules that are hydrogen bonded to the 17-OH. If one of the two water molecules is included in the distance measurement, there is a perfect fit with the two OH groups of DES. This suggests that water may have an important role for estradiol in its receptor site.
It is now generally accepted that the estrogens must have a phenolic moiety for binding, but some investigators propose that the receptor may be flexible enough to accommodate varying distances between the two key hydroxyls. This point about estrogens needing a phenolic ring for high-affinity binding to the ER is critical. Steroids with a phenolic A ring and related phenolic compounds lack high-affinity binding to the other steroid hormone receptors.
Test Report
ITEMS | SPECIFICATION EP6/USP32 | RESULTS |
CHARACTERS(PH.EUR.) | A WHITE OR ALMOST WHITE,CRYSTALLINE POWDER | COMPLIES |
SOLUBILITY(PH.EUR.) | PRACTICALLY INSOLUBLE IN WATER,SPARINGLY SOLUBLE IN ACETONE AND IN ALCOHOL,SLIGHTLY IN METHYLENE CHLORIDE | COMPLIES |
IDENTIFICATION | ||
A.IR-SPECTRUM(PH.EUR) | MEETS THE REQUIREMENT | COMPLIES |
B.TLC(PH.EUR) | MEETS THE REQUIREMENT | COMPLIES |
A.IR-SPECTRUM(USP) | MEETS THE REQUIREMENT | COMPLIES |
B.UV ABSORPTION(USP) | MEETS THE REQUIREMENT | COMPLIES |
SPECIFIC OPTICAL ROTATION | ||
(PH.EUR) | BETWEEN+150°AND +156° | +152.1° |
(USP) | BETWEEN+150°AND +156° | +153.3° |
LOSS ON DRYING | ||
(PH.EUR) | NOT MORE THAN 1.0% | 0.04% |
(USP) | NOT MORE THAN 1.0% | 0.05% |
RESIDUE ON IGNITION(USP) | NEGLIGIBLE,FROM 100MG | COMPLIES |
RELATED SUBSTANCES(PH.EUR) | ||
ANY INDIVIDUAL IMPURITY | NOT MORE THAN 0.5% | 0.30% |
SUM OF IMPURITIES | NOT MORE THAN 1.5% | 1.24% |
CHROMATOGRAPHIC PURITY(USP) | ||
ANY INDIVIDUAL IMPURITY | NOT MORE THAN 0.5% | 0.28% |
SUM OF IMPURITIES | NOT MORE THAN 2.0% | 1.25% |
ASSAY | ||
UV ABSORPTION(PH.EUR.) | BETWEEN 97.0% AND 103.0% | 100.70% |
HPLC(USP) | BETWEEN 97.0% AND 102.0% | 98.70% |
RESIDUAL SOLVENT(IN-HOUSE) | ||
METHANOL | NOT MORE THAN 500PPM | NOT DETECT OUT |
ETHANOL | NOT MORE THAN 2000PPM | 455PPM |
METHYLENE CHLORIDE | NOT MORE THAN 600PPM | NOT DETECT OUT |
CONCLUSION:THE PRODUCT CONFORMS TO PH.EUR.6/USP34 | ||
FAQ
1. Who are we?
We are based in Shaanxi, China, start from 2018,sell to North America(00.00%),Western Europe(00.00%),South America(00.00%),Southeast Asia(00.00%),Eastern Europe(00.00%). There are total about 11-50 people in our office.
2. How can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.What can you buy from us?
Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates
4. Why should you buy from us not from other suppliers?
Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement , the quality and technical content can reach the advance level in China .Our products are sold well in China as well as in more than 20 countries
5. What services can we provide?
Accepted Delivery Terms: FOB,CFR,CIF,EXW,Express Delivery;
Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
Accepted Payment Type: T/T,L/C,MoneyGram,Credit Card,Western Union,Cash,Escrow;
Language Spoken:English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian.
Company Profile
Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
Package & Delivery & Payment Terms
Why Choose Us?
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Contact Us
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