<sub>Topotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy. 

In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The 3 clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome. 

Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors.

Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.</sub> 

_{Xi'an Tian guangyuan Biotech Co.,Ltd.}

_{Tel: 86-29-86333380}

_{Fax: 86-29-86333380}

_{Web:tgybio.en.made-in-china.com}
 

<sub>We have more than 500 vendors, we could save your effort to serve customers with supplying all your needs!

1. We has 10 years' exporting experience in active pharmaceutical ingredient products.
Our professionaland thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

1> Any inquiries will be replied within 12 hours.
2> Dedication to quality, supply & service.
3> Strictly on selecting raw materials.
4> Reasonable & competitive price, fast lead time.</sub>
 

<sub>XI'AN Tian Guangyuan Biotech Co.,Ltd.was founded in May 2003, is a professional animal and plant extracts modern and advanced enterprise object, chemical intermediates and active ingredients of natural active throughout the country, plant extracts industry, research and development, production, marketing and other areas have a strong strength.

The company is headquartered in the outskirts of Xi'an, under research and development center as well as analysis and testing center, comprehensive strength in the national forefront of the industry.
Companies rely on the wisdom and innovation of advanced technology, scientific management and all the staff and a good team spirit, will enable the company to develop a domestic industry with sik-class product quality and international competitiveness of enterprises.
Thank you for your interest in our products.</sub>

_{1. Can I buy a sample for evaluation?} 

_{Yes, a small percentage of items are available for single-unit sample purchases online. To make it easier for our customers to locate these items, a separate section in our store will be created soon. For now, if an item offers samples, Click on the link to order the sample.}

_{2. How to make payment?} 

_{We accept payment by telegraphic transfer (T/T) and Western Union .}

_{3. How much does shipping cost?} 

_{Shipping costs vary according to the shipping method and your ship-to country. For your easy reference, the estimated shipping cost you see in your shopping cart is based on courier shipping to the United States. The system will indicate the actual shipping cost based on your selected shipping method 
and ship-to country when you checkout and before you commit to the purchase. Generally, shipping to the UK and other Western European countries is slightly more expensive than to the USA. And shipping to  Asia is slightly less expensive than to the USA.}

_{4. Does the shipping cost cover local taxes, import duties, and other import-related costs?} 

_{The shipping cost does not cover any local taxes, import duties, customs clearance, or any other import-related costs levied by your government. The buyer is responsible for these import-related costs. Please check with your local customs office for more information.}

_{5. What shipping options do I have?} 

_{In our continued effort to offer value and flexibility to our customers, we will be offering four different options to deliver your order.}

_{1-200kg Carrier express(DHL/UPS/Fedex/EMS)} 

_{300kg-500kg by air}

_{6. How long is lead time?} 

_{We deliver goods within 3 days for small order, 7-10 days for bulk order.}