Factory Supply Raw Powder Amiodarone Hydrochloride CAS 19774-82-4 with Best Price
China Factory Supply Raw Powder Amiodarone Hydrochloride CAS 19774-82-4 with Best Price, Find details about China Amiodarone Hydrochloride, CAS 19774-82-4 from Factory Supply Raw Powder Amiodarone Hydrochloride CAS 19774-82-4 with Best Price
Basic Info.
Model NO.
Amiodarone hydrochloride
Product Name
Amiodarone Hydrochloride
CAS No.
19774-82-4
Molecular Formula
C25h29I2no3.Clh
Molecular Weight
681.77
Melting Point
154-158°c
Boiling Point
N/a
Density
N/a
Trademark
SENWAYER
Transport Package
Foil Bag
Specification
1kg /bag
Origin
China
HS Code
29322090
Model NO.
Amiodarone hydrochloride
Product Name
Amiodarone Hydrochloride
CAS No.
19774-82-4
Molecular Formula
C25h29I2no3.Clh
Molecular Weight
681.77
Melting Point
154-158°c
Boiling Point
N/a
Density
N/a
Trademark
SENWAYER
Transport Package
Foil Bag
Specification
1kg /bag
Origin
China
HS Code
29322090
Product Desciption
Factory Supply Raw Powder Amiodarone hydrochloride CAS 19774-82-4 with Best Price
| Product name | Amiodarone hydrochloride |
| CAS number | 19774-82-4 |
| Molecular formula | C25H29I2NO3.ClH |
| Molecular weight | 681.77 |
| Appearance | White Powder |
| Purity | 99.0% |
| Description | Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. IC50 Value: 1.5 uM ( inhibit TBARS, LOOH and FPL formation)[1]in vitro: It was found that 10 uM amiodarone induces accumulation of ethidium bromide (5 ug/ml) in Saccharomyces cerevisiae cells. At the same time, in yeast cells with inactivated MDR genes, accumulation of ethidium bromide was 6-fold higher even without amiodarone. Addition of non-lethal concentrations of amiodarone to MDR-deficient cells caused an increase of intracellular ethidium bromide to the level, which was even lower than the level in amiodarone-treated wild-type cells [2]. Cells treated with amiodarone were seen to have detached from the dish, with cell rounding, cytoplasmic blebbing and irregularity in shape. An increase in the sub-G1 phase fraction, from 15.43 to 21.34% and 79.83% and a reduction in the G1 phase fraction, from 48.83 to 41.63% and 11.52%, were observed in cells treated with amiodarone at concentrations of 0.1 and 1 mM, respectively [3].in vivo: Chronic treatment with oral amiodarone for 4 weeks reduced i.p. when myocytes were dialyzed with patch-pipettes containing either 10 mM Na+ or 80 mM Na+. In myocytes from untreated rabbits, acute exposure to amiodarone in vitro reduced i.p. when patch pipettes contained 10 mM Na+ but had no effect on i.p. at 80 mM Na+. Amiodarone had no effect on the voltage dependence of the pump or the affinity of the pump for extracellular K+ either after chronic treatment or during acute exposure [4].Clinical trial: Continuous Versus Episodic Amiodarone Treatment for the Prevention of Permanent Atrial Fibrillation. |
Amiodarone hydrochloride can prevent some paroxysmal or ventricular tachycardia and ventricular fibrillation. It is also suitable for improving paroxysmal ventricular tachycardia when the drug effect is poor. It is also suitable for paroxysmal atrial flutter and atrial fibrillation.
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