Antithrombotic Raw Materials Streptozotocin Veterinary Streptozotocin Powder Streptozotocin
China Antithrombotic Raw Materials Streptozotocin Veterinary Streptozotocin Powder Streptozotocin, Find details about China Streptozotocin, Streptozotocin Powder from Antithrombotic Raw Materials Streptozotocin Veterinary Streptozotocin Powder Streptozotocin
| Product Name | Streptozotocin |
| CAS NO. | 18883-66-4 |
| Purity | 99% |
| density | 1.86 |
| Appearance and shape | Yellow powder |
Streptozotocin belongs to glucosamine-nitrosourea, which is a DNA alkylation reagent that can enter cells by GLUT2 glucose transport protein (GLUT2 glucose transport protein) alone. Toxic to insulin-induced β-cells. Streptozotocin has a toxic effect on GLUT2-positive neuroendocrine tumor cells.
On October 27, 2017, the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization was preliminarily compiled for reference, and streptozotocin was included in the list of 2B carcinogens.
1. Treatment of islet cell tumors (β-cell or non-β-cell carcinoma).
2. It has a certain effect on carcinoid tumors, Hodgkin's disease, colon cancer and liver cancer.
3. Establish animal models of type 1 diabetes in medical research.
4. Streptozotocin is selectively absorbed by islet cells and has a cytotoxic effect on malignant islet cell tumors. Therefore, it is mainly applied to metastatic islet cell tumors (including insulin-secreting and non-insulin-secreting β-cells and non-β cells). Can cause tumor shrinkage (35% response rate) and return to normal blood sugar levels.
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