China Supply High Quality API Teriparatide Acetate Powder, Find details about China Teriparatide Acetate Powder, Teriparatide Acetate from China Supply High Quality API Teriparatide Acetate Powder
Name | Teriparatide acetate |
CAS No. | 52232-67-4 |
Purity | >99% |
Molecular Formula | C181H291N55O51S2 |
Molecular weight | 4177.77 |
Appearance | White Powder |
Storage temp | Freeze dried at -20ºC, protected from light |
Teriparatide is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent[1] used in the treatment of some forms of osteoporosis.It is also occasionally used off-label to speed fracture healing. Teriparatide is identical to a portion of human parathyroid hormone (PTH) and intermittent use activates osteoblasts more than osteoclasts, which leads to an overall increase in bone.
Teriparatide is the only anabolic (i.e., bone growing) agent indicated for use in postmenopausal women with osteoporosis at a high risk for fracture or with a history of osteoporotic fracture, patients with multiple risk factors for fracture, and for patients who have failed or are intolerant to other available osteoporosis therapy. It has been FDA-approved since 2002. It is effective in growing bone (e.g., 8% increase in bone density in the spine after one year) and reducing the risk of fragility fractures. Osteoporosis medications are generally safe, but some side effects of teriparatide include headache, nausea, dizziness, and limb pain.
1.Helping restore the suppleness and firmness of skin.
2.Increase HA and collage,anti-aging.
3. Producing chemotaxis for reconstructing and repair, reconstruction of dermis,significantly stimulated human skin fibroblast proliferation.
4.Based on glycerin water solution,absorbed easily by skin.
TEST ITEMS | SPECIFICATIONS | RESULTS |
Appearance | White powder | Conforms |
Solubility | Soluble in water or 1% acetic acid | Conforms |
at a concentration of ≥1mg/ml to | ||
give a clear, colorless solution | ||
Specific Optical Rotation(c=0.5,1% HAc) | - -65.0~-75.0° | -70.2° |
Identity | Monoisotopic Mass: 4117.7±2.0 | 4116 |
Amino Acid Composition | ±20% | Conforms |
Related Substances | Total Impurities(%)≤ 5.0% | 0.80% |
Largest Single Impurity(%)≤ 2.0% | 0.30% | |
Peptide Purity (By HPLC) | ≥ 95.0% by area integration | 99.30% |
Acetate Content | ≤ 15% | 9.00% |
Water Content(Karl Fischer) | ≤ 8.0% | 2.50% |
Peptide Content(N determination) | ≥ 80.0% | 88.30% |
Assay(By Anhydrous, Acetic Acid-free ) | 95.0~105.0% | 99.00% |