Leflunomide Active Pharmaceutical Ingredient CAS 75706-12-6
China Leflunomide Active Pharmaceutical Ingredient CAS 75706-12-6, Find details about China Leflunomide, Hwa 486 from Leflunomide Active Pharmaceutical Ingredient CAS 75706-12-6
Basic Info.
Model NO.
Leflunomide
Trademark
xingjiu
Transport Package
Bag/Drum
Specification
99%
Origin
China
Model NO.
Leflunomide
Trademark
xingjiu
Transport Package
Bag/Drum
Specification
99%
Origin
China
Product Desciption
Leflunomide Active Pharmaceutical Ingredient CAS 75706-12-6
Leflunomide Basic information
Leflunomide Chemical Properties
Leflunomide Chemical Properties
White crystalline powder, melting at 166.5 ºC.
Leflunomide Uses
(1) It is hydrogenated acid dehydrogenase inhibitor with immunosuppressive and anti-inflammatory effects for the treatment of adults with active rheumatoid arthritis.
(2) Nonsteroidal anti-inflammatory drug.
Packing and Shipping
1) 1 kg with double plastic container inside/Aluminum foil bag .
2) 1-5 kg,carton.
Shipped in 3 days after payment.
Payment Terms
Leflunomide Basic information
| Product Name: | Leflunomide |
| Synonyms: | LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE;5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide;Teriflunomide Impurity 12 |
| CAS: | 75706-12-6 |
| MF: | C12H9F3N2O2 |
| MW: | 270.21 |
| EINECS: | 616-254-6 |
| Product Categories: | Other APIs;An immunosuppressive agent;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Active Pharmaceutical Ingredients;API;Osteoarthritis and Rheumatoid Arthritis;Aromatics;Heterocycles;CARDENE |
Leflunomide Chemical Properties
| Melting point | 166.5 °C |
| Boiling point | 289.3±40.0 °C(Predicted) |
| density | 1.392±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in methanol, sparingly soluble in methylene chloride. |
| pka | 10.8(at 25ºC) |
| form | neat |
| Merck | 14,5432 |
| InChIKey | VHOGYURTWQBHIL-UHFFFAOYSA-N |
| CAS DataBase Reference | 75706-12-6(CAS DataBase Reference) |
Leflunomide Chemical Properties
White crystalline powder, melting at 166.5 ºC.
Leflunomide Uses
(1) It is hydrogenated acid dehydrogenase inhibitor with immunosuppressive and anti-inflammatory effects for the treatment of adults with active rheumatoid arthritis.
(2) Nonsteroidal anti-inflammatory drug.
Polyvinylpyrrolidone Definition
A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.
Polyvinylpyrrolidone Description
Leflunomide is an orally-available disease-modifying antirheumatic drug and was launched as Arava in the US for the treatment of rheumatoid arthritis (RA) ; it is the first and only drug to be indicated to slow down structural joint damage of RA, so addressing an unmet medical need.
Leflunomide is prepared in 3 steps from the appropriate acetoacetic anilide using a nitrile oxide- enamine cycloaddition reaction to assemble the isoxazole ring. Leflunomide is a prodrug, being extensively metabolized in vivo into the corresponding 2-cyano-3-hydroxy-2-butenamide resulting from fragmentation of the isoxazole ring. This cyanoenol is actually the active metabolite and several experiments in animals have demonstrated that after oral administration, substantial and sustained levels of this metabolite were delivered to the systemic circulation.
In vitro, Leflunomide's active metabolite inhibits dihydroorotate dehydrogenase, an enzyme involved in the biosynthesis of pyrimidine nucleotides, probably accounting for its immunosuppressive effect in vivo. Other mechanisms of action such as inhibition of tyrosine kinase and inhibition of responsiveness to interleukin-2 have been proposed. In diverse models of autoimmune or allergic diseases, Leflunornide showed efficacy both prophylactically and therapeutically.
Our Factory
A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.
Polyvinylpyrrolidone Description
Leflunomide is an orally-available disease-modifying antirheumatic drug and was launched as Arava in the US for the treatment of rheumatoid arthritis (RA) ; it is the first and only drug to be indicated to slow down structural joint damage of RA, so addressing an unmet medical need.
Leflunomide is prepared in 3 steps from the appropriate acetoacetic anilide using a nitrile oxide- enamine cycloaddition reaction to assemble the isoxazole ring. Leflunomide is a prodrug, being extensively metabolized in vivo into the corresponding 2-cyano-3-hydroxy-2-butenamide resulting from fragmentation of the isoxazole ring. This cyanoenol is actually the active metabolite and several experiments in animals have demonstrated that after oral administration, substantial and sustained levels of this metabolite were delivered to the systemic circulation.
In vitro, Leflunomide's active metabolite inhibits dihydroorotate dehydrogenase, an enzyme involved in the biosynthesis of pyrimidine nucleotides, probably accounting for its immunosuppressive effect in vivo. Other mechanisms of action such as inhibition of tyrosine kinase and inhibition of responsiveness to interleukin-2 have been proposed. In diverse models of autoimmune or allergic diseases, Leflunornide showed efficacy both prophylactically and therapeutically.
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Our Factory
Xingtai Xingjiu New Material Technology Co., Ltd. was founded in 2018 and located in Xingtai City, Hebei Province.Our company aims to be a leading materials science company in innovation, customer orientation, inclusiveness and sustainability, committed to the sustainable development of society through our expertise in materials science and deep collaboration with our customers.
Xingjiu company products industrial intermediates, cosmetics raw materials, solvents and other daily chemical raw materials, to provide customers with a wide range of technology based differentiated products and right solutions.Our goal is to become a leading manufacturer of chemicals.With vigorous and progressive spirit and strong competitive strength, the company will strive to provide customers with high quality industrial products and excellent service, in order to achieve the lofty goals.
Xingjiu company adheres to the four core values of customer first, team building, innovation and responsibility to achieve the common development of the company and the society.If you are interested in our products, please send us emails or call us.We will get back to you in time.
Xingjiu company products industrial intermediates, cosmetics raw materials, solvents and other daily chemical raw materials, to provide customers with a wide range of technology based differentiated products and right solutions.Our goal is to become a leading manufacturer of chemicals.With vigorous and progressive spirit and strong competitive strength, the company will strive to provide customers with high quality industrial products and excellent service, in order to achieve the lofty goals.
Xingjiu company adheres to the four core values of customer first, team building, innovation and responsibility to achieve the common development of the company and the society.If you are interested in our products, please send us emails or call us.We will get back to you in time.
Packing and Shipping
1) 1 kg with double plastic container inside/Aluminum foil bag .
2) 1-5 kg,carton.
3) 25 kg with double plastic container inside/Fiber drum outside.
Or as your request.Shipped in 3 days after payment.
| Fast | Suitable | |
| DHL / FEDEX / EMS | 3-7 days | 50 kg |
| By Air | 5-15 days | > 50kg |
| By Sea | 10-45 days | > 1000kg |
Payment Terms
How To Proceed You Oreder:
1: Please let me know the items you are favorable, quantities, and the destination country.
2: You confirm all detail, and offer purchasing order.
3: We send the detail price of our product and offer the suitable shipping method for reference.
4: You confirm the order and pay mony 100% in advance and send us the detailed contacting information, including contacting person/company, address, mobile number, ZIP code and your special requirements.
5: We arrange the shipment according to your requirements, and tracking code will be offered after claiming the payment within 24h, then you can track your parcel at any moment.
6: We offer after-sales services after service after you receive your parcel.
Why Choose Us
1. the customer comes first, we provide reasonable price, high quality product and prompt shipment
2. We can send the goods to your delivery address directly. it is relatively safe and fast. We have ready goods in stock.
3. quick and clear response to customers questions.
warm after sale service, we will help to solve the problems in your wusge.
4. we could make our price discount if you place a substanial order with us.
1: Please let me know the items you are favorable, quantities, and the destination country.
2: You confirm all detail, and offer purchasing order.
3: We send the detail price of our product and offer the suitable shipping method for reference.
4: You confirm the order and pay mony 100% in advance and send us the detailed contacting information, including contacting person/company, address, mobile number, ZIP code and your special requirements.
5: We arrange the shipment according to your requirements, and tracking code will be offered after claiming the payment within 24h, then you can track your parcel at any moment.
6: We offer after-sales services after service after you receive your parcel.
Why Choose Us
1. the customer comes first, we provide reasonable price, high quality product and prompt shipment
2. We can send the goods to your delivery address directly. it is relatively safe and fast. We have ready goods in stock.
3. quick and clear response to customers questions.
warm after sale service, we will help to solve the problems in your wusge.
4. we could make our price discount if you place a substanial order with us.
FAQ
Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable.
Q2. What about the lead time?
A:Sample needs 3-5 days, mass production time needs 1-2 weeks for order quantity more than
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How to proceed an order for your products?
A: Firstly let us know your requirements or application.
Secondly We quote according to your requirements or our suggestions.
Thirdly customer confirms the samples and places deposit for formal order.
Fourthly We arrange the production.
If you have any other needs, please contact me.
Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable.
Q2. What about the lead time?
A:Sample needs 3-5 days, mass production time needs 1-2 weeks for order quantity more than
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How to proceed an order for your products?
A: Firstly let us know your requirements or application.
Secondly We quote according to your requirements or our suggestions.
Thirdly customer confirms the samples and places deposit for formal order.
Fourthly We arrange the production.
If you have any other needs, please contact me.
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