Peptide Pnc27 Pnc -27 Peptide Pnc27

China Peptide Pnc27 Pnc-27 Peptide Pnc27, Find details about China Pnc-27, Medical Peptide Pnc-27 from Peptide Pnc27 Pnc-27 Peptide Pnc27

Model NO.
SWY-PNC 27
Colour
White
Transport Package
Box
Specification
75iu/VIALS, 10 VIALS /BOX
Origin
Shaanxi
Model NO.
SWY-PNC 27
Colour
White
Transport Package
Box
Specification
75iu/VIALS, 10 VIALS /BOX
Origin
Shaanxi
Peptide Pnc27 Pnc-27 Peptide Pnc27

Name: PNC-27
Sequence:  PPLSQETFSDLWKLL
Molecular formula: C84H128N18O24
Molecular weight: 1772.93
Purity:  >98.0%
Specication : 2mg/vial, 10vials/box
Source :  synthetic
Keywords : PNC-27

PNC-27 is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells. 

PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in contrast to the effects of many chemotherapeutic agents.

 
 
 
 
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Peptide Pnc27 Pnc-27 Peptide Pnc27Peptide Pnc27 Pnc-27 Peptide Pnc27

Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products,
wewon't keep stock and it needs time to synthesize.

Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over
5years, in average.Strict quality control-comes form our sophisticated management system.Professional and warm sales team-since we
believe we can only win via our hard work in a competitive worldQuick response and excellent presale and after sale service-since
we believe our customers deserve all the best service.

Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can alsoenjoy
fun of bargaining. Just don't make it too hard!

Q6: How should I pay?
A: We accept all kinds of payment ways. such as alibaba trade asssurance, T/T, West union, MoneyGram.

Peptide Pnc27 Pnc-27 Peptide Pnc27