Propranolol Hydrochloride Tablets to Reduce Mortality From Myocardial Infarction as a Secondary Prevention
China Propranolol Hydrochloride Tablets to Reduce Mortality From Myocardial Infarction as a Secondary Prevention, Find details about China Propranolol Hydrochloride Tablets, Propranolol Hydrochloride from Propranolol Hydrochloride Tablets to Reduce Mortality From Myocardial Infarction as a Secondary Prevention
Basic Info.
Model NO.
CF055
Model NO.
CF055
Product Desciption
General name propranolol hydrochloride tablets
Main Ingredients The main ingredient of this product is propranolol hydrochloride.
Chemical name: 1-isopropylamino-3 -(1-naphthoxy) -2-propanol hydrochloride.
Indications 1. Reduces mortality from myocardial infarction as a secondary prevention.
2. Hypertension (alone or in combination with other antihypertensive drugs).
3. Labor angina pectoris.
4. Control supraventricular tachyarrhythmia, ventricular arrhythmia, especially related to catecholamines or digitalism-induced arrhythmia. It can be used to control the ventricular rate of atrial fluttery and atrial fibrillation with poor efficacy of digitalis, and can also be used to improve the symptoms of patients with intractable prephase contraction.
5. Reduce the pressure difference of outflow tract of hypertrophic cardiomyopathy, and relieve angina pectoris, palpitations and fainting, etc.
6. Tachycardia control in patients with pheochromocytoma in combination with alpha blockers.
7. Used to control hyperthyroidism of the heart rate is too fast, can also be used to treat thyroid crisis.
Adverse reactions Application of this product can appear vertigo, mental confusion (especially in the elderly), mental depression, slow reaction and other central nervous system adverse reactions; Dizziness (caused by hypotension); Heart rate is too slow (< 50 beats/min); Rarely have bronchospasm and dyspnea, congestive heart failure; More rare are fever and sore throat (granulocytosis), rash (anaphylaxis), bleeding tendency (thrombocytopenia); When adverse reactions persist, extra vigilance should be given to cold limbs, diarrhea, tiredness, dry eyes and mouth or skin, nausea, numbness of fingers and toes, abnormal fatigue, etc.
Contraindications 1. Bronchial asthma.
2. Cardiogenic shock.
3. Heart block (- primary atrioventricular block).
Severe or acute heart failure.
5. Sinus bradycardia.
1. This product can be taken orally on an empty stomach or in combination with food, which can delay metabolism in liver and improve bioavailability.
2. The tolerance of beta blockers varies greatly among individuals, so the amount must be individualized. The first time to use this product should be small dose, gradually increase the dose and closely observe the reaction to avoid accidents.
3. Note that the blood concentration of this product can not fully predict the pharmacological effect, so clinical medication should be guided according to clinical signs such as heart rate and blood pressure.
4. Patients with coronary heart disease should not stop suddenly when using this product, otherwise angina pectoris, myocardial infarction or ventricular tachycardia may occur.
5. Patients with hyperthyroidism should not stop using this product, otherwise the symptoms of hyperthyroidism will be aggravated.
6. Long-term use of this product to withdraw the drug should gradually reduce the dosage, at least 3 days, generally 2 weeks.
7. Long-term application of this product may occur in a small number of patients with heart failure, if the occurrence of digitalis glycosides and/or diuretics can be used to correct, and gradually reduce the dose, and finally discontinued.
8. This product can reduce blood glucose in diabetic patients, but it has no hypoglycemic effect in non-diabetic patients. Therefore, diabetic patients should check their blood sugar regularly.
9. Regular check of blood routine, blood pressure, heart function, liver and kidney function, etc., during taking this product.
10. Interruptions to diagnosis: when taking this product, the determination of blood urea nitrogen, lipoprotein, creatinine, potassium, triglyceride, uric acid and so on May be increased, while the blood sugar decreases. But people with diabetes sometimes get taller. The metabolites of this product can accumulate in the blood and interfere with the determination of the diazo reaction of serum choleronycin, resulting in false positivity.
11. Use this product with caution in the following situations: history of allergy, congestive heart failure, diabetes, emphysema or non-allergic bronchial asthma, liver insufficiency, hypothyroidism, Raynaud's syndrome or other peripheral vascular diseases, renal decline, etc.
Pregnant women and nursing mothers use of this product can be through the placenta into the fetus, have reported gestational hypertension after use can result in intrauterine fetal developmental delays, childbirth is unable to cause during childbirth, the newborn can produce low blood pressure, low blood sugar, respiratory depression, and the heart rate slows, although reports have no influence on both mother and fetus, but must be careful, not as the first line treatment for pregnant women. This product can be a small amount of secretion from milk, so lactating women with caution.
The medication for children has not been determined yet. Generally, 0.5 ~ 1.0mg/kg per day is taken orally in times according to body weight. The therapeutic range of blood concentration of this product is similar to that of adults according to the weight of children. However, according to the body surface area of children, the therapeutic range of blood concentration of this product is higher than that of adults. It has been reported that when patients with congenital fooliness take this product, blood drug concentration increases, thus improving bioavailability.
Elderly medication because of the elderly patients to the drug metabolism and excretion ability is low, the use of this product should be appropriate to adjust the dosage.
1. Interaction with antihypertensive agents: When used in combination with reserpine, this product may cause postural hypotension, bradycardia, dizziness, and syncope. When used in combination with monoamine oxidase inhibitors, it can cause extreme hypotension.
2. When combined with digitalis, atrioventricular block may occur and the heart rate may slow down, which requires close observation.
3. When used in combination with calcium antagonists, especially intravenous verapamil, be very alert to the inhibition of the myocardium and the conduction system.
4. Combined with epinephrine, phenyleforine, or sympathetic amines, it can cause significant hypertension, slow heart rate, and atrioventricular block.
5. Combined with isoproterenol or xanthine, the efficacy of the latter can be weakened.
6. When combined with haloperidol, it can cause hypotension and cardiac arrest.
7. Intral absorption of propranolol can be reduced when used in combination with alumina hydroxide gel.
8. Alcohol can slow down the absorption rate of this product.
9. Use in combination with phenytoin sodium, phenobarbital and rifampicin to accelerate the removal of this product.
10. Combined with chlorpromazine can increase the blood concentration of both drugs.
11. Combined with antipyrine, theophylline and lidocaine can reduce the clearance rate of this product.
12. Combined use with thyroxine resulted in a decrease in T3 concentration.
13. Combined with cimetidine can reduce the liver metabolism of this product, delay elimination, and increase the blood concentration of propranolol.
14. It can affect the blood glucose level, so when used with hypoglycemic drugs, the dose of the latter should be adjusted.
Drug overdose In general, if drug overdose, gastric contents should be emptying as soon as possible to prevent aspiration pneumonia. Atropine was given in bradycardia, and isoproterenol was used with caution. Install a pacemaker if necessary. Lidocaine or phenytoin sodium were given to patients with ventricular early onset. Take digitalis or diuretics when heart failure occurs. Give hypotensive drugs, such as norepinephrine or epinephrine, when you have low blood pressure. Adrenaline or aminophylline is given for bronchial asthma. This drug cannot be discharged on dialysis.
Drug toxicology 1 pharmacological action
(1) Propranolol is a nonselective competitive inhibitor of adrenergic beta receptor blocker. It can be used for the treatment of angina pectoris by blocking the β1 and β2 receptors on the heart, antagonizing the sympathetic nerve excitation and catecholamine action, reducing the systolic force and systolic speed of the heart, inhibiting the contraction of vascular smooth muscle, reducing the oxygen consumption of the myocardium, and restoring the balance of oxygen supply and demand of the ischemic myocardium at a low level.
(2) adrenaline that inhibits cardiac pacemaker potential can excite and is used to treat arrhythmias. This product can also through the central, adrenergic neurons block, inhibit the release of renin and reduce the amount of cardiac output, used in the treatment of hypertension.
(3) Competently antagonize the effects of isoproterenol and norepinephrine, block β2 receptor, and decrease the activity of plasma renin. It can cause bronchospasm. Inhibit insulin secretion, make blood glucose rise, cover up hypoglycemia symptoms, delay the recovery of hypoglycemia.
(4) It has obvious anti-platelet aggregation effect, which is mainly related to the membrane stabilization and inhibition of platelet membrane Ca2+ transport.
2. Carcinogenesis, mutagenesis and reproductive toxicity
For 18 months, rats or mice were given 150mg/kg daily for 18 months with no significant toxic reactions and no drug-related carcinogenic effects. No reproductive impairment associated with propranolol was observed in reproductive experiments. Embryonic toxicity is shown when given to animals at a dose 10 times that of human use.
Pharmacokinetics After oral administration, the product is completely absorbed in the gastrointestinal tract, widely metabolized in the liver, and the bioavailability is about 30%. The peak concentration of plasma drug reached 1 ~ 1.5 hours after treatment, the elimination half-life was 2 ~ 3 hours, and the plasma protein binding rate was 90% ~ 95%. There were significant differences in blood drug concentrations among individuals, and the apparent volume of distribution was (3.9±6.0)L/kg. Excrete by the kidney, mainly metabolites, a small part (<1%) as the parent drug. It cannot be discharged by dialysis.
Storage Storage sealed storage.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
Main Ingredients The main ingredient of this product is propranolol hydrochloride.
Chemical name: 1-isopropylamino-3 -(1-naphthoxy) -2-propanol hydrochloride.
Indications 1. Reduces mortality from myocardial infarction as a secondary prevention.
2. Hypertension (alone or in combination with other antihypertensive drugs).
3. Labor angina pectoris.
4. Control supraventricular tachyarrhythmia, ventricular arrhythmia, especially related to catecholamines or digitalism-induced arrhythmia. It can be used to control the ventricular rate of atrial fluttery and atrial fibrillation with poor efficacy of digitalis, and can also be used to improve the symptoms of patients with intractable prephase contraction.
5. Reduce the pressure difference of outflow tract of hypertrophic cardiomyopathy, and relieve angina pectoris, palpitations and fainting, etc.
6. Tachycardia control in patients with pheochromocytoma in combination with alpha blockers.
7. Used to control hyperthyroidism of the heart rate is too fast, can also be used to treat thyroid crisis.
Adverse reactions Application of this product can appear vertigo, mental confusion (especially in the elderly), mental depression, slow reaction and other central nervous system adverse reactions; Dizziness (caused by hypotension); Heart rate is too slow (< 50 beats/min); Rarely have bronchospasm and dyspnea, congestive heart failure; More rare are fever and sore throat (granulocytosis), rash (anaphylaxis), bleeding tendency (thrombocytopenia); When adverse reactions persist, extra vigilance should be given to cold limbs, diarrhea, tiredness, dry eyes and mouth or skin, nausea, numbness of fingers and toes, abnormal fatigue, etc.
Contraindications 1. Bronchial asthma.
2. Cardiogenic shock.
3. Heart block (- primary atrioventricular block).
Severe or acute heart failure.
5. Sinus bradycardia.
1. This product can be taken orally on an empty stomach or in combination with food, which can delay metabolism in liver and improve bioavailability.
2. The tolerance of beta blockers varies greatly among individuals, so the amount must be individualized. The first time to use this product should be small dose, gradually increase the dose and closely observe the reaction to avoid accidents.
3. Note that the blood concentration of this product can not fully predict the pharmacological effect, so clinical medication should be guided according to clinical signs such as heart rate and blood pressure.
4. Patients with coronary heart disease should not stop suddenly when using this product, otherwise angina pectoris, myocardial infarction or ventricular tachycardia may occur.
5. Patients with hyperthyroidism should not stop using this product, otherwise the symptoms of hyperthyroidism will be aggravated.
6. Long-term use of this product to withdraw the drug should gradually reduce the dosage, at least 3 days, generally 2 weeks.
7. Long-term application of this product may occur in a small number of patients with heart failure, if the occurrence of digitalis glycosides and/or diuretics can be used to correct, and gradually reduce the dose, and finally discontinued.
8. This product can reduce blood glucose in diabetic patients, but it has no hypoglycemic effect in non-diabetic patients. Therefore, diabetic patients should check their blood sugar regularly.
9. Regular check of blood routine, blood pressure, heart function, liver and kidney function, etc., during taking this product.
10. Interruptions to diagnosis: when taking this product, the determination of blood urea nitrogen, lipoprotein, creatinine, potassium, triglyceride, uric acid and so on May be increased, while the blood sugar decreases. But people with diabetes sometimes get taller. The metabolites of this product can accumulate in the blood and interfere with the determination of the diazo reaction of serum choleronycin, resulting in false positivity.
11. Use this product with caution in the following situations: history of allergy, congestive heart failure, diabetes, emphysema or non-allergic bronchial asthma, liver insufficiency, hypothyroidism, Raynaud's syndrome or other peripheral vascular diseases, renal decline, etc.
Pregnant women and nursing mothers use of this product can be through the placenta into the fetus, have reported gestational hypertension after use can result in intrauterine fetal developmental delays, childbirth is unable to cause during childbirth, the newborn can produce low blood pressure, low blood sugar, respiratory depression, and the heart rate slows, although reports have no influence on both mother and fetus, but must be careful, not as the first line treatment for pregnant women. This product can be a small amount of secretion from milk, so lactating women with caution.
The medication for children has not been determined yet. Generally, 0.5 ~ 1.0mg/kg per day is taken orally in times according to body weight. The therapeutic range of blood concentration of this product is similar to that of adults according to the weight of children. However, according to the body surface area of children, the therapeutic range of blood concentration of this product is higher than that of adults. It has been reported that when patients with congenital fooliness take this product, blood drug concentration increases, thus improving bioavailability.
Elderly medication because of the elderly patients to the drug metabolism and excretion ability is low, the use of this product should be appropriate to adjust the dosage.
1. Interaction with antihypertensive agents: When used in combination with reserpine, this product may cause postural hypotension, bradycardia, dizziness, and syncope. When used in combination with monoamine oxidase inhibitors, it can cause extreme hypotension.
2. When combined with digitalis, atrioventricular block may occur and the heart rate may slow down, which requires close observation.
3. When used in combination with calcium antagonists, especially intravenous verapamil, be very alert to the inhibition of the myocardium and the conduction system.
4. Combined with epinephrine, phenyleforine, or sympathetic amines, it can cause significant hypertension, slow heart rate, and atrioventricular block.
5. Combined with isoproterenol or xanthine, the efficacy of the latter can be weakened.
6. When combined with haloperidol, it can cause hypotension and cardiac arrest.
7. Intral absorption of propranolol can be reduced when used in combination with alumina hydroxide gel.
8. Alcohol can slow down the absorption rate of this product.
9. Use in combination with phenytoin sodium, phenobarbital and rifampicin to accelerate the removal of this product.
10. Combined with chlorpromazine can increase the blood concentration of both drugs.
11. Combined with antipyrine, theophylline and lidocaine can reduce the clearance rate of this product.
12. Combined use with thyroxine resulted in a decrease in T3 concentration.
13. Combined with cimetidine can reduce the liver metabolism of this product, delay elimination, and increase the blood concentration of propranolol.
14. It can affect the blood glucose level, so when used with hypoglycemic drugs, the dose of the latter should be adjusted.
Drug overdose In general, if drug overdose, gastric contents should be emptying as soon as possible to prevent aspiration pneumonia. Atropine was given in bradycardia, and isoproterenol was used with caution. Install a pacemaker if necessary. Lidocaine or phenytoin sodium were given to patients with ventricular early onset. Take digitalis or diuretics when heart failure occurs. Give hypotensive drugs, such as norepinephrine or epinephrine, when you have low blood pressure. Adrenaline or aminophylline is given for bronchial asthma. This drug cannot be discharged on dialysis.
Drug toxicology 1 pharmacological action
(1) Propranolol is a nonselective competitive inhibitor of adrenergic beta receptor blocker. It can be used for the treatment of angina pectoris by blocking the β1 and β2 receptors on the heart, antagonizing the sympathetic nerve excitation and catecholamine action, reducing the systolic force and systolic speed of the heart, inhibiting the contraction of vascular smooth muscle, reducing the oxygen consumption of the myocardium, and restoring the balance of oxygen supply and demand of the ischemic myocardium at a low level.
(2) adrenaline that inhibits cardiac pacemaker potential can excite and is used to treat arrhythmias. This product can also through the central, adrenergic neurons block, inhibit the release of renin and reduce the amount of cardiac output, used in the treatment of hypertension.
(3) Competently antagonize the effects of isoproterenol and norepinephrine, block β2 receptor, and decrease the activity of plasma renin. It can cause bronchospasm. Inhibit insulin secretion, make blood glucose rise, cover up hypoglycemia symptoms, delay the recovery of hypoglycemia.
(4) It has obvious anti-platelet aggregation effect, which is mainly related to the membrane stabilization and inhibition of platelet membrane Ca2+ transport.
2. Carcinogenesis, mutagenesis and reproductive toxicity
For 18 months, rats or mice were given 150mg/kg daily for 18 months with no significant toxic reactions and no drug-related carcinogenic effects. No reproductive impairment associated with propranolol was observed in reproductive experiments. Embryonic toxicity is shown when given to animals at a dose 10 times that of human use.
Pharmacokinetics After oral administration, the product is completely absorbed in the gastrointestinal tract, widely metabolized in the liver, and the bioavailability is about 30%. The peak concentration of plasma drug reached 1 ~ 1.5 hours after treatment, the elimination half-life was 2 ~ 3 hours, and the plasma protein binding rate was 90% ~ 95%. There were significant differences in blood drug concentrations among individuals, and the apparent volume of distribution was (3.9±6.0)L/kg. Excrete by the kidney, mainly metabolites, a small part (<1%) as the parent drug. It cannot be discharged by dialysis.
Storage Storage sealed storage.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
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