Valaciclovir Hydrochloride High Purity 99% CAS No. 124832 -27-5 Apis Raw Material

China Valaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw Material, Find details about China Valaciclovir Hydrochloride, CAS No. 124832-27-5 from Valaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw Material

Basic Info.

Model NO.

CAS NO. 124832-27-5

Appearance

White, Crystalline Powder

Transport Package

25kg/Drum

Origin

China

HS Code

293359909

Model NO.

CAS NO. 124832-27-5

Appearance

White, Crystalline Powder

Transport Package

25kg/Drum

Origin

China

HS Code

293359909

Product Desciption

Valaciclovir Hydrochloride Purity 99% CAS NO. 124832-27-5 APIs Raw Material

Basic Information:

Valacyclovir hydrochloride Chemical Properties
Melting point	170-172°C
storage temp.	Refrigerator
solubility	H2O: >20mg/mL
form	solid
color	white
λmax	253nm(H2O)(lit.)
Merck	14,9899
CAS DataBase Reference	124832-27-5(CAS DataBase Reference)

Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent genital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.