Valaciclovir Hydrochloride High Purity 99% CAS No. 124832 -27-5 Apis Raw Material

China Valaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw Material, Find details about China Valaciclovir Hydrochloride, CAS No. 124832-27-5 from Valaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw Material

Model NO.
CAS NO. 124832-27-5
Appearance
White, Crystalline Powder
Transport Package
25kg/Drum
Origin
China
HS Code
293359909
Model NO.
CAS NO. 124832-27-5
Appearance
White, Crystalline Powder
Transport Package
25kg/Drum
Origin
China
HS Code
293359909
Valaciclovir Hydrochloride Purity 99% CAS NO. 124832-27-5 APIs Raw Material 

Basic Information: 
 
Valacyclovir hydrochloride Chemical Properties
Melting point 170-172°C
storage temp. Refrigerator
solubility H2O: >20mg/mL
form solid
color white
λmax253nm(H2O)(lit.)
Merck 14,9899
CAS DataBase Reference124832-27-5(CAS DataBase Reference)
     
Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent genital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.



 
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Valaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw MaterialValaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw Material

Valaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw MaterialValaciclovir Hydrochloride High Purity 99% CAS No. 124832-27-5 Apis Raw Material