Synthetic Anti-Infective Drugs CAS 192725 -17-0 Lopinavir
China Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir, Find details about China Lopinavir, Lopinavir Powder from Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir
Basic Info.
Model NO.
HNB-280
Trademark
HNB-Biotech
Transport Package
Aluminium Foil Bag, Cardboard Drum
Origin
Shaanxi, China
Model NO.
HNB-280
Trademark
HNB-Biotech
Transport Package
Aluminium Foil Bag, Cardboard Drum
Origin
Shaanxi, China
Product Desciption
Synthetic anti-infective drugs CAS 192725-17-0 Lopinavir
Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.Target: HIV proteaseLopinavir is a potent inhibitor of Rh123 efflux in Caco-2 monolayers with IC50 of 1.7 mM. Lopinavir exposure (72 hours) in LS 180V cells reduces the content of intracellular Rh123. Lopinavir induces P-glycoprotein immunoreactive protein and messenger RNA levels in LS 180V cells. Lopinavir inhibits subtype C clone C6 with IC50 of 9.4 nM. Lopinavir inhibits CYP3A with IC50 of 7.3 mM in human liver microsomes, while produces negligible or weak inhibition of human CYP1A2, 2B6, 2C9, 2C19 and 2D6. Lopinavir (10 mg/kg, orally) results in Cmax of 0.8 μg/mL and oral bioavailability of 25% in rats.
| Product name | Lopinavir |
| Cas No. | 192725-17-0 |
| Molecular Formula | C37H48N4O5 |
| Appearance | White powder |
Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.Target: HIV proteaseLopinavir is a potent inhibitor of Rh123 efflux in Caco-2 monolayers with IC50 of 1.7 mM. Lopinavir exposure (72 hours) in LS 180V cells reduces the content of intracellular Rh123. Lopinavir induces P-glycoprotein immunoreactive protein and messenger RNA levels in LS 180V cells. Lopinavir inhibits subtype C clone C6 with IC50 of 9.4 nM. Lopinavir inhibits CYP3A with IC50 of 7.3 mM in human liver microsomes, while produces negligible or weak inhibition of human CYP1A2, 2B6, 2C9, 2C19 and 2D6. Lopinavir (10 mg/kg, orally) results in Cmax of 0.8 μg/mL and oral bioavailability of 25% in rats.
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