Rifampicin Capsules Used in Combination with Other Antituberculous Agents for The Initial and Subsequent Treatment of Various Forms of Tuberculosis
China Rifampicin Capsules Used in Combination with Other Antituberculous Agents for The Initial and Subsequent Treatment of Various Forms of Tuberculosis, Find details about China Rifampicin Capsules, Rifampicin from Rifampicin Capsules Used in Combination with Other Antituberculous Agents for The Initial and Subsequent Treatment of Various Forms of Tuberculosis
Basic Info.
Model NO.
CF076
Model NO.
CF076
Product Desciption
Product name: rifampicin capsule
The generic name is rifampicin capsule
Main Ingredients The main ingredient is rifampicin.
Indications 1. This product is used in combination with other antituberculous agents for the initial and subsequent treatment of various forms of tuberculosis, including tuberculous meningitis.
2. This product is used in combination with other drugs for the treatment of leprosy and non-tuberculous mycobacterium infection.
3. This product and vancomycin (IV) can be used in combination for serious infection caused by methicillin-resistant staphylococcus, and the combination of rifampicin and erythromycin can be used for serious infection of Legionella.
4. For asymptomatic carriers of Neisseria meningitidis to eliminate Neisseria meningitidis from the nasopharynx, but not for the treatment of Neisseria meningitidis infection.
1. Gastrointestinal reactions are the most common. After oral administration of this product, anorexia, nausea, vomiting, upper abdominal discomfort, diarrhea and other gastrointestinal reactions may occur, with the incidence of 1.7% ~ 4.0%, but they are all tolerable.
2. Hepatotoxicity is the main adverse reaction of this product, with an incidence of about 1%. In the first few weeks of treatment, a few patients may show elevated serum aminotransferase, hepatomegaly and jaundice, most of which are asymptomatic transient elevated serum aminotransferase, which can recover spontaneously during the course of treatment. Elderly people, alcoholics, poor nutrition, existing liver disease or other factors caused by abnormal liver function are more likely to occur.
3. Hypersensitivity After high-dose interval therapy, "influenza-like syndrome" may occasionally appear, showing chills, chills, fever, malaise, dyspnea, dizziness, drowsiness and muscle pain, etc. The frequency of occurrence is significantly related to dose size and interval time.
4. Occasionally, acute hemolysis or renal failure may occur, and the mechanism is currently believed to be allergic reaction.
5. After other patients take this product, urine and feces, saliva, sputum, tears, etc., may appear orange red.
6. Occasionally leukopenia, shortened prothrombin time, headache, vertigo, visual impairment, etc.
Contraindications 1. It is forbidden for people allergic to this product or rifamycin.
2. It is contraindicated for patients with severe liver function insufficiency, biliary obstruction and pregnant women within 3 months.
Precautions 1. Alcohol poisoning and liver function damage should be used with caution.
2. Interference with diagnosis:
(1) It can lead to direct anti-globulin test (Coombs test) positive.
(2) interfering with the determination of serum folic acid concentration and serum vitamin B12 concentration.
(3) can make sodium sulfonophthalide test residual false positive.
(4) may interfere with the results of various urinalysis tests using spectrophotometers or color changes.
(5) It can increase the concentration of blood urea nitrogen, serum alkaline phosphatase, serum alanine aminotransferase, aspartate aminotransferase, serum bilirubin and serum uric acid.
3. Rifampin can cause liver function is not complete, the original liver disease or this product with other drug hepatotoxicity suits with jaundice deaths reported from time to tome, so the original liver disease patients, only under the condition with clear indications can be careful, before the start of treatment, treatment, close observation of liver function, liver damage once appear, immediately.
4. Hyperbilirubinemia is a mixture of hepatocellular and bile retention. Patients with mild symptoms will subside spontaneously during medication, while patients with severe symptoms need to stop medication for observation.
5. When rifampicin is used alone to treat tuberculosis or other bacterial infections, the pathogen can quickly develop resistance. Therefore, this product must be used in combination with other drugs. Treatment may take six months to two years, or even years.
6. Rifampicin may cause leukopenia and thrombocytopenia, gingival bleeding and infection, delayed wound healing, etc. At this time, we should avoid operations such as tooth extraction, pay attention to oral hygiene, brush teeth and pick teeth carefully, until blood images return to normal. Peripheral blood images should be checked regularly during medication.
7. Rifampicin should be taken 1 hour before or 2 hours after a meal. It is best to take it once in the morning on an empty stomach because eating will affect the absorption of this product.
8. Patients with decreased liver function often need to reduce the dose, daily dose ≤8mg/kg.
9. It is not necessary to reduce the dose in patients with reduced renal function. Blood concentrations of rifampicin did not change significantly in patients with reduced glomerular filtration rate or anuria.
10. After taking medicine, urine, saliva, sweat and other excreta can show orange red.
1. Rifampicin can pass through the placenta and has caused teratogenesis in animal experiments. Although teratogenicity has not been reported in humans, there is not enough data to indicate that it can be used safely during pregnancy. It is forbidden for pregnant women under 3 months, and should be used with caution for pregnant women over 3 months.
2. Rifampicin can be excreted by breast milk. Lactating women should fully weigh the pros and cons of drug use before deciding.
1. The safety of this product has not been established in children under 5 years of age.
2. Use with caution to infants.
The liver function of old age patient with old age medication drops to some extent, dosage should be reduced discretionally.
1. Drinking alcohol can increase the incidence of rifampicin hepatotoxicity and increase the metabolism of rifampicin, so the dose of rifampicin should be adjusted and the occurrence of hepatotoxicity in patients should be closely observed.
2. Amino salicylate can affect the absorption of this product, resulting in the reduction of its blood concentration; If a combination is necessary, take at least 6 hours between the two.
3. Combined use of this product with isoniazid increases the risk of hepatotoxicity, especially in patients with original liver function impairment and isoniazid rapid acetylation.
4. Adverse reactions can be aggravated by the combination of rifampicin and ethionotinamide.
5. Chlorophenoxazine can reduce the absorption of rifampicin, delay the peak time and prolong the half-life.
6. Rifampicin should not be used with imidazoles because it can reduce the plasma concentration of the latter two drugs when used in combination with imiconazole or ketoconazole.
7. Adrenal cortical hormone (glucocorticoids, mineralocorticoid), anticoagulants, aminophylline, theophylline, chloramphenicol, chlorine as ester, ring cell element, verapamil (verapamil), appropriate to carney, propafenone, benzyl methyl oxygen organism, coumarin, or indan diketone derivatives, fall blood sugar medicine oral, corticotrophin, dapsone, digitalis glycosides, c pyrazole amine, quinidine and rifampicin share, etc , the latter induces the activity of liver microsomal enzyme, which can reduce the efficacy of the above drugs. Therefore, except digoxin and dapsone, the dosage of the above drugs should be adjusted before and during the course of rifampicin administration. The prothrombin time should be measured daily or regularly when this product is combined with coumarin or indene diketone, so as to adjust the dosage.
8. This product can promote the metabolism of estrogen or reduce its intestinal liver circulation, reduce the effect of oral contraceptives, resulting in irregular menstruation, menstrual bleeding and unplanned pregnancy. Therefore, patients taking rifu peacetime, should be converted to other contraceptive methods.
9. This product can induce liver microsomal enzymes and increase the metabolism of anti-tumor drugs dacarbazine and cyclophosphamide, resulting in the formation of alkylated metabolites and the decrease of white blood cells. Therefore, dosage adjustment is required.
10. The combination of this product with diazepam (diazepam) can increase the elimination of the latter and reduce its blood concentration, so it is necessary to adjust the dosage.
11. This product can increase the metabolism of phenytoin in the liver, so the concentration of phenytoin in blood should be measured and the dosage should be adjusted when the two are used together.
12. This product can increase the degradation of levothyroxine in the liver, so the dosage of levothyroxine should be increased when the two are used together.
13. This product can also increase the metabolism of methadone and methadone in the liver, causing methadone withdrawal symptoms and decreased methadone concentration in the blood, so the dosage should be adjusted after the combination of the two.
14. Acetoxamil can compete with this product for uptake by hepatocytes, increasing the plasma concentration of this product and producing toxic reactions. However, this effect is not stable, so it is usually not appropriate to add propane to increase the blood concentration of this product.
1. Signs of overdose: mental retardation; Edema around the eyes or face; Itching all over the body; Red man syndrome (red or orange skin mucosa and sclera), primary liver disease, may cause death in alcoholics or with other hepatotoxic drugs.
2. Processing:
(1).
(2) Gastric lavage. Because patients often suffer from nausea and vomiting, it is not appropriate to emetic again. Activated carbon paste should be given after gastric lavage to absorb the residual rifampicin in the gastrointestinal tract.
(3) Intravenous infusion and diuretics were given to promote the excretion of drugs.
Drug toxicology 1. Rifampicin is a semi-synthetic broad-spectrum antimicrobial drug of rifamycin class, which has antimicrobial activity against a variety of pathogenic microorganisms:
(1) The drug has obvious bactericidal effect on Mycobacterium tuberculosis and some non-Mycobacterium tuberculosis (including Mycobacterium leprosy, etc.) in and out of host cells.
(2) Rifampicin has good antimicrobial effect on aerobic gram-positive bacteria, including enzyme-producing strains of Staphylococcus and methicillin-resistant strains, Streptococcus pneumoniae, other streptococcus genera, Enterococcus genera, Listeria genera, Bacillus anthracis, Perfringens, Diphtheria bacillus, anaerobic coccus, etc.
(3) It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae and Neisseria gonorrhoeae.
(4) Rifampicin also had a good effect on Legionella, and had an inhibitory effect on pathogens such as Chlamydia trachomatis, lymphogranuloma of venereal diseases and parrots fever.
2. Bacteria had cross resistance to rifamycin antibiotics.
3. Rifampicin binds firmly to the β-subunit of DNA-dependent RNA polymerase, inhibits bacterial RNA synthesis and prevents the enzyme from connecting with DNA, thus blocking the RNA transcription process and stopping the synthesis of DNA and protein.
Pharmacokinetics 1. Rifampicin is well absorbed by oral administration, with peak plasma concentration 1.5 ~ 4 hours after taking the drug. The peak plasma concentration (Cmax) is 7-9 mg/L after a single oral administration of 600mg for adults and 10mg/kg for children aged 6 months to 5 years, with a peak plasma concentration (Cmax) of 11mg/L.
2. This product is well distributed in most tissues and body fluids, including cerebrospinal fluid. When meningeal inflammation occurs, the concentration of the drug in cerebrospinal fluid increases, and the effective therapeutic concentration can also be reached in saliva.
3. This product can cross the placenta.
4. The apparent volume of distribution (VD) was 1.6L/kg, and the protein binding rate was 80% ~ 91%. The absorption of the drug could be reduced by 30% by taking the drug after eating, and the blood elimination half-life (t1/2) of the drug was 3-5 hours, which was shortened to 2-3 hours after repeated administration.
5. This product in the liver can be induced microsomal oxidase action and rapid deacetylation, become antibacterial activity of the metabolite deacetylrifampicin, hydrolysis after the formation of inactive metabolite excreted from the urine.
6. This article mainly by the bravery and intestinal excretion, can enter the enterohepatic circulation, but its to acetyl active metabolite enterohepatic circulation, dosage of 60% ~ 65% by the eduction of excrement and urine, 6% ~ 15% of the drugs to prototype, 15% active metabolite through urine, the activity of 7%, with no 3 - formyl derivatives, through breast milk.
7. There was no accumulation of this product in patients with renal dysfunction.
8. Due to the effect of self-induced liver microsomal oxidase, the excretion rate increases after 6-10 days of rifampicin administration, and may be delayed after high doses due to the saturation of biliary tract excretion.
9. Rifampicin could not be cleared by hemodialysis or peritoneal dialysis.
Store sealed in a dark and dry place.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
The generic name is rifampicin capsule
Main Ingredients The main ingredient is rifampicin.
Indications 1. This product is used in combination with other antituberculous agents for the initial and subsequent treatment of various forms of tuberculosis, including tuberculous meningitis.
2. This product is used in combination with other drugs for the treatment of leprosy and non-tuberculous mycobacterium infection.
3. This product and vancomycin (IV) can be used in combination for serious infection caused by methicillin-resistant staphylococcus, and the combination of rifampicin and erythromycin can be used for serious infection of Legionella.
4. For asymptomatic carriers of Neisseria meningitidis to eliminate Neisseria meningitidis from the nasopharynx, but not for the treatment of Neisseria meningitidis infection.
1. Gastrointestinal reactions are the most common. After oral administration of this product, anorexia, nausea, vomiting, upper abdominal discomfort, diarrhea and other gastrointestinal reactions may occur, with the incidence of 1.7% ~ 4.0%, but they are all tolerable.
2. Hepatotoxicity is the main adverse reaction of this product, with an incidence of about 1%. In the first few weeks of treatment, a few patients may show elevated serum aminotransferase, hepatomegaly and jaundice, most of which are asymptomatic transient elevated serum aminotransferase, which can recover spontaneously during the course of treatment. Elderly people, alcoholics, poor nutrition, existing liver disease or other factors caused by abnormal liver function are more likely to occur.
3. Hypersensitivity After high-dose interval therapy, "influenza-like syndrome" may occasionally appear, showing chills, chills, fever, malaise, dyspnea, dizziness, drowsiness and muscle pain, etc. The frequency of occurrence is significantly related to dose size and interval time.
4. Occasionally, acute hemolysis or renal failure may occur, and the mechanism is currently believed to be allergic reaction.
5. After other patients take this product, urine and feces, saliva, sputum, tears, etc., may appear orange red.
6. Occasionally leukopenia, shortened prothrombin time, headache, vertigo, visual impairment, etc.
Contraindications 1. It is forbidden for people allergic to this product or rifamycin.
2. It is contraindicated for patients with severe liver function insufficiency, biliary obstruction and pregnant women within 3 months.
Precautions 1. Alcohol poisoning and liver function damage should be used with caution.
2. Interference with diagnosis:
(1) It can lead to direct anti-globulin test (Coombs test) positive.
(2) interfering with the determination of serum folic acid concentration and serum vitamin B12 concentration.
(3) can make sodium sulfonophthalide test residual false positive.
(4) may interfere with the results of various urinalysis tests using spectrophotometers or color changes.
(5) It can increase the concentration of blood urea nitrogen, serum alkaline phosphatase, serum alanine aminotransferase, aspartate aminotransferase, serum bilirubin and serum uric acid.
3. Rifampin can cause liver function is not complete, the original liver disease or this product with other drug hepatotoxicity suits with jaundice deaths reported from time to tome, so the original liver disease patients, only under the condition with clear indications can be careful, before the start of treatment, treatment, close observation of liver function, liver damage once appear, immediately.
4. Hyperbilirubinemia is a mixture of hepatocellular and bile retention. Patients with mild symptoms will subside spontaneously during medication, while patients with severe symptoms need to stop medication for observation.
5. When rifampicin is used alone to treat tuberculosis or other bacterial infections, the pathogen can quickly develop resistance. Therefore, this product must be used in combination with other drugs. Treatment may take six months to two years, or even years.
6. Rifampicin may cause leukopenia and thrombocytopenia, gingival bleeding and infection, delayed wound healing, etc. At this time, we should avoid operations such as tooth extraction, pay attention to oral hygiene, brush teeth and pick teeth carefully, until blood images return to normal. Peripheral blood images should be checked regularly during medication.
7. Rifampicin should be taken 1 hour before or 2 hours after a meal. It is best to take it once in the morning on an empty stomach because eating will affect the absorption of this product.
8. Patients with decreased liver function often need to reduce the dose, daily dose ≤8mg/kg.
9. It is not necessary to reduce the dose in patients with reduced renal function. Blood concentrations of rifampicin did not change significantly in patients with reduced glomerular filtration rate or anuria.
10. After taking medicine, urine, saliva, sweat and other excreta can show orange red.
1. Rifampicin can pass through the placenta and has caused teratogenesis in animal experiments. Although teratogenicity has not been reported in humans, there is not enough data to indicate that it can be used safely during pregnancy. It is forbidden for pregnant women under 3 months, and should be used with caution for pregnant women over 3 months.
2. Rifampicin can be excreted by breast milk. Lactating women should fully weigh the pros and cons of drug use before deciding.
1. The safety of this product has not been established in children under 5 years of age.
2. Use with caution to infants.
The liver function of old age patient with old age medication drops to some extent, dosage should be reduced discretionally.
1. Drinking alcohol can increase the incidence of rifampicin hepatotoxicity and increase the metabolism of rifampicin, so the dose of rifampicin should be adjusted and the occurrence of hepatotoxicity in patients should be closely observed.
2. Amino salicylate can affect the absorption of this product, resulting in the reduction of its blood concentration; If a combination is necessary, take at least 6 hours between the two.
3. Combined use of this product with isoniazid increases the risk of hepatotoxicity, especially in patients with original liver function impairment and isoniazid rapid acetylation.
4. Adverse reactions can be aggravated by the combination of rifampicin and ethionotinamide.
5. Chlorophenoxazine can reduce the absorption of rifampicin, delay the peak time and prolong the half-life.
6. Rifampicin should not be used with imidazoles because it can reduce the plasma concentration of the latter two drugs when used in combination with imiconazole or ketoconazole.
7. Adrenal cortical hormone (glucocorticoids, mineralocorticoid), anticoagulants, aminophylline, theophylline, chloramphenicol, chlorine as ester, ring cell element, verapamil (verapamil), appropriate to carney, propafenone, benzyl methyl oxygen organism, coumarin, or indan diketone derivatives, fall blood sugar medicine oral, corticotrophin, dapsone, digitalis glycosides, c pyrazole amine, quinidine and rifampicin share, etc , the latter induces the activity of liver microsomal enzyme, which can reduce the efficacy of the above drugs. Therefore, except digoxin and dapsone, the dosage of the above drugs should be adjusted before and during the course of rifampicin administration. The prothrombin time should be measured daily or regularly when this product is combined with coumarin or indene diketone, so as to adjust the dosage.
8. This product can promote the metabolism of estrogen or reduce its intestinal liver circulation, reduce the effect of oral contraceptives, resulting in irregular menstruation, menstrual bleeding and unplanned pregnancy. Therefore, patients taking rifu peacetime, should be converted to other contraceptive methods.
9. This product can induce liver microsomal enzymes and increase the metabolism of anti-tumor drugs dacarbazine and cyclophosphamide, resulting in the formation of alkylated metabolites and the decrease of white blood cells. Therefore, dosage adjustment is required.
10. The combination of this product with diazepam (diazepam) can increase the elimination of the latter and reduce its blood concentration, so it is necessary to adjust the dosage.
11. This product can increase the metabolism of phenytoin in the liver, so the concentration of phenytoin in blood should be measured and the dosage should be adjusted when the two are used together.
12. This product can increase the degradation of levothyroxine in the liver, so the dosage of levothyroxine should be increased when the two are used together.
13. This product can also increase the metabolism of methadone and methadone in the liver, causing methadone withdrawal symptoms and decreased methadone concentration in the blood, so the dosage should be adjusted after the combination of the two.
14. Acetoxamil can compete with this product for uptake by hepatocytes, increasing the plasma concentration of this product and producing toxic reactions. However, this effect is not stable, so it is usually not appropriate to add propane to increase the blood concentration of this product.
1. Signs of overdose: mental retardation; Edema around the eyes or face; Itching all over the body; Red man syndrome (red or orange skin mucosa and sclera), primary liver disease, may cause death in alcoholics or with other hepatotoxic drugs.
2. Processing:
(1).
(2) Gastric lavage. Because patients often suffer from nausea and vomiting, it is not appropriate to emetic again. Activated carbon paste should be given after gastric lavage to absorb the residual rifampicin in the gastrointestinal tract.
(3) Intravenous infusion and diuretics were given to promote the excretion of drugs.
Drug toxicology 1. Rifampicin is a semi-synthetic broad-spectrum antimicrobial drug of rifamycin class, which has antimicrobial activity against a variety of pathogenic microorganisms:
(1) The drug has obvious bactericidal effect on Mycobacterium tuberculosis and some non-Mycobacterium tuberculosis (including Mycobacterium leprosy, etc.) in and out of host cells.
(2) Rifampicin has good antimicrobial effect on aerobic gram-positive bacteria, including enzyme-producing strains of Staphylococcus and methicillin-resistant strains, Streptococcus pneumoniae, other streptococcus genera, Enterococcus genera, Listeria genera, Bacillus anthracis, Perfringens, Diphtheria bacillus, anaerobic coccus, etc.
(3) It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae and Neisseria gonorrhoeae.
(4) Rifampicin also had a good effect on Legionella, and had an inhibitory effect on pathogens such as Chlamydia trachomatis, lymphogranuloma of venereal diseases and parrots fever.
2. Bacteria had cross resistance to rifamycin antibiotics.
3. Rifampicin binds firmly to the β-subunit of DNA-dependent RNA polymerase, inhibits bacterial RNA synthesis and prevents the enzyme from connecting with DNA, thus blocking the RNA transcription process and stopping the synthesis of DNA and protein.
Pharmacokinetics 1. Rifampicin is well absorbed by oral administration, with peak plasma concentration 1.5 ~ 4 hours after taking the drug. The peak plasma concentration (Cmax) is 7-9 mg/L after a single oral administration of 600mg for adults and 10mg/kg for children aged 6 months to 5 years, with a peak plasma concentration (Cmax) of 11mg/L.
2. This product is well distributed in most tissues and body fluids, including cerebrospinal fluid. When meningeal inflammation occurs, the concentration of the drug in cerebrospinal fluid increases, and the effective therapeutic concentration can also be reached in saliva.
3. This product can cross the placenta.
4. The apparent volume of distribution (VD) was 1.6L/kg, and the protein binding rate was 80% ~ 91%. The absorption of the drug could be reduced by 30% by taking the drug after eating, and the blood elimination half-life (t1/2) of the drug was 3-5 hours, which was shortened to 2-3 hours after repeated administration.
5. This product in the liver can be induced microsomal oxidase action and rapid deacetylation, become antibacterial activity of the metabolite deacetylrifampicin, hydrolysis after the formation of inactive metabolite excreted from the urine.
6. This article mainly by the bravery and intestinal excretion, can enter the enterohepatic circulation, but its to acetyl active metabolite enterohepatic circulation, dosage of 60% ~ 65% by the eduction of excrement and urine, 6% ~ 15% of the drugs to prototype, 15% active metabolite through urine, the activity of 7%, with no 3 - formyl derivatives, through breast milk.
7. There was no accumulation of this product in patients with renal dysfunction.
8. Due to the effect of self-induced liver microsomal oxidase, the excretion rate increases after 6-10 days of rifampicin administration, and may be delayed after high doses due to the saturation of biliary tract excretion.
9. Rifampicin could not be cleared by hemodialysis or peritoneal dialysis.
Store sealed in a dark and dry place.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
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