China High Quaity Chemical API Topiroxostat with Good Price CAS 577778-58-6, Find details about China Topiroxostat, Fyx 051 from High Quaity Chemical API Topiroxostat with Good Price CAS 577778-58-6
Chemical Name | 4-(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyridine-2-carbonitrile |
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Synonyms | 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile;4-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-2-Pyridinecarbonitrile;Topiroxostat;Topiroxostat [INN];Uriadec (TN);Expand |
CAS No. | 577778-58-6 |
Molecular Formula | C13H8N6 |
Molecular Weight | 248.24300 |
PSA | 91.14000 |
LogP | 1.80038 |
Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate. Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia. In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis. Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 μM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.
Batch No. | HF171121 | Quantity | 8.5kgs |
Mfg. Date | Nov. 21, 2017 | Package | As required |
Rep. Date | Nov. 25, 2017 | Exp. Date | Nov. 20, 2019 |
Items | Standards | Results | |
Appearance | White or off-white solid powder | Complies | |
Identification | By IR | Complies | |
By HPLC | Complies | ||
Solubility | Soluble in DMF, sparingly soluble in THF, slightly soluble in methanol and acetonitrile, very sightly soluble in ethanol and dichloromethane, insoluble in water | Complies | |
Polymorphic Form | Polymorphic form 1 | Complies | |
Melting Point | 211ºC~216ºC | 212.8ºC~214.9ºC | |
Water Content | ≤ 0.50% | 0.10% | |
Heavy Metals | ≤ 20ppm | Complies | |
Residue on Ignition | ≤ 0.20% | 0.09% | |
Related Substance | Any single impurity: ≤0.10% | 0.06% | |
Total Impurities: ≤1.00% | 0.16% | ||
Assay (on the anhydrous basis) | 98.0%~102.0% | 99.94% | |
Particle Size | D90: ≤100µm | Complies | |
Reference Standard | In-house Standard | ||
Conclusion | The product complied to In-house standard. | ||
Storage | Preserve in tight,light-resistant containers in a cool place |