China Pharmaceutical Intermediate Topiroxostat Powder with Best Price, Find details about China Cheap Price Topiroxostat, Quality Control Topiroxostat from Pharmaceutical Intermediate Topiroxostat Powder with Best Price
Name | Topiroxostat |
Synonyms | 5-(2-Cyano-4-pyridyl)-3-(4-pyridyl)-1,2,4-triazole; FYX 051 |
Brand | Salus |
Molecular Formula | C13H8N6 |
Molecular Weight | 248.24 |
CAS Registry Number | 577778-58-6 |
Shelf Life | 2 years |
Appearance | White or off-white crystalline powder |
Brand Name: | Oriherb |
Form | Powder |
Place of Origin: | Shaanxi, China (Mainland) |
Packaging: | Bottle, Can, Drum, Plastic Contain |
Standard: | USP EP JP etc. |
Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate. Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia. In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis. Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 μM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.
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