Sulbutiamine was developed in Japan as a more efficient version of vitamin B1. vitamin B1 (thiamine) is an essential nootropic vitamin and sulbutiamine mimics the effects of Thiamine at a more drastic level. Sulbutiamine is more efficient than thiamine at crossing the blood brain barrier and therefore much stronger in terms of effects. Sulbutiamine brings its own set of unique properties and can be used alone or stacked with other nootropics.

Method of Action

It is believed that sulbutiamine works similarly to thiamine however the effects are greatly enhanced. Thiamine is essential in the body and even more essential for cognitive function because it is used in the biosynthesis of acetylcholine and GABA.  sulbutiamine is believed to have effects on the cholinergic, glutamatergic and dopamine systems which result in its nootropic benefits.

Thiamine is inferior to sulbutimaine in its absorption rate. It is absorbed through the intestines at a poor rate that is often reduced by hindrances like folic deficiency. Having higher concentrations of Thiamine in the digestive tract will also reduce this absorption rate even further. Sulbutiamine is much more lipophilic and is able to dissolve in fats. This not only gives it a better absorption rate but more importantly, increases blood brain barrier efficiency.

Sulbutiamine Benefits

Sulbutiamine has long been used as an over-the-counter nootropic. Certain studies have pointed it to improving memory function. This is likely due to its influence on acetylcholine and glutamate activity. Influence of D1 dopamine receptor function may also aid in added cognitive benefits.

Sulbutiamine seems to have a mild stimulant effects in some. Many athletes were using it as a legal performance enhancer in sports and it is quite popular in these communities. Sulbutimaine does not seem to affect the other catecholamines other than dopamine so it does not have a tendency to trigger your typical amphetamine-stimulant side effects.