Nmae:Orlistat
CAS Number: 96829-58-2
EINECS: 115074-43-6
Molecular formula: C17H19N3O3S
Molecular weight: 495.73
Appearance: White to Off-white powder
Melting point: 42-46 °


DESCRIPTION
Orlistat is now internationally recognized as a new weight loss and fat lowering drug, the market is sold under the trade name of Seneca, the first in New Zealand in 1998. Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor, white or white-like powder at room temperature, insoluble in water, soluble in chloroform, and soluble in ethanol. It inactivates the enzyme by forming covalent bonds with the active serine sites of gastric lipase and pancreatic fat Chemicalbook enzymes in the stomach and small intestinal lumen. The fat in food cannot decompose free fatty acid and monacyl glycerin, because this adipose cannot be absorbed and use, reduce the quantity of heat of human body to absorb thereby, control weight.

APPLICATION
1. Orlistat is a lipase inhibitor weight-loss drug. It is a hydrated derivative of lipstatin, which can reduce the absorption of food fat, thus leading to weight loss. This product has a strong and selective inhibitory effect on gastric lipase and pancreatic fat Chemicalbook enzyme, and has no effect on other digestive enzymes (amylase, trypsin, chymotrypsin) and phospholipase, and does not affect the absorption of carbohydrates, proteins and phospholipids. The drug is not absorbed by the gastrointestinal tract and has a reversible inhibitory effect on lipase.

2. This product also has the function of regulating blood lipid: it can reduce the triglyceride (TG) in the serum of obese patients, low-density lipoprotein cholesterol ldl-c and increase the ratio of high-density lipoprotein to low-density lipoprotein.

Pay attention to
This product, in combination with a mild low-calorie diet, is suitable for long-term treatment of obese and overweight patients, including those who already have obesity-related risk factors. Chemicalbook has the long-term efficacy of weight control (weight loss, weight maintenance and prevention of rebound). Taking orlistat can lower the risk factors associated with obesity and the incidence of other diseases associated with obesity, including hypercholesterolemia, diabetes, reduce glucose tolerance, insulin hematic disease, high blood pressure, and can reduce the fat content of viscera