Products

China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest, Find details about China (2R 4S) -Ketoconazole, Brizoral from China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

Model NO.
265-667-4
CAS
65277-42-1
Einecs
265-667-4
Molecular Weight
531.431
Boiling Point
753.4±60.0 °c at 760 Mmhg
Density
1.4±0.1 g/cm3
Molecular Formula
C26h28cl2n4o4
Melting Point
146°c
Flash Point
409.4±32.9 °c
Psa
69.06000
Vapour Pressure
0.0±2.5 Mmhg at 25°c
Water Solubility
Soluble in DMSO, Ethanol, Chlorofor, Water, and M
Appearance
White Fine Powder
Solubility
Methano: Soluble50mg/Ml
Storage Temp.
2-8°c
Index of Refraction
1.642
Trademark
Wuhan Mulei
Transport Package
Packing Within 3 Working Days
Specification
25kg/Cardboard barrel
Origin
Hebei
HS Code
2933990090
Model NO.
265-667-4
CAS
65277-42-1
Einecs
265-667-4
Molecular Weight
531.431
Boiling Point
753.4±60.0 °c at 760 Mmhg
Density
1.4±0.1 g/cm3
Molecular Formula
C26h28cl2n4o4
Melting Point
146°c
Flash Point
409.4±32.9 °c
Psa
69.06000
Vapour Pressure
0.0±2.5 Mmhg at 25°c
Water Solubility
Soluble in DMSO, Ethanol, Chlorofor, Water, and M
Appearance
White Fine Powder
Solubility
Methano: Soluble50mg/Ml
Storage Temp.
2-8°c
Index of Refraction
1.642
Trademark
Wuhan Mulei
Transport Package
Packing Within 3 Working Days
Specification
25kg/Cardboard barrel
Origin
Hebei
HS Code
2933990090
Product Description

 

Ketoconazole
 

 
Ketoconazole structure
China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest
 
Common NameKetoconazole
CAS Number65277-42-1Molecular Weight531.431
Density1.4±0.1 g/cm3Boiling Point753.4±60.0 °C at 760 mmHg
Molecular FormulaC26H28Cl2N4O4Melting Point146°C
MSDSChineseUSAFlash Point409.4±32.9 °C
Symbol   
GHS06, GHS08, GHS09		Signal WordDanger

 Use of Ketoconazole

 
Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.Target: CYP3A4 CYP24A1Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosteron levels, in men being treated for chronic mycotic infections [1]. Ketoconazole also is a cytochrome P450 inhibitor [2].Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver.[3] CYP24A1 inhibitor enhances antiproliferative effects, increases systemic calcitriol exposure, and promotes the activation of caspase-independent apoptosis pathway.[4]
  
    
    
    
    
    
 
China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest
Ketoconazole (Nizoral) is approved for treating dermatophyte infections unresponsive to griseofulvin and for patients unable to tolerate that drug. A single oral dose is also effective for the treatment of pityriasis versicolor. Other effective drugs that are less hepatotoxic may be preferred, however.Ketoconazole (Nizoral) is a broad-spectrum antifungal agent that in very high doses inhibits several steps in the biosynthesis of both adrenal and gonadal steroids. While the normal antifungal dose is 200 mg/day, testosteron biosynthesis in both the adrenal and testis is completely abolished by doses of 800 to 1,600 mg/day. This drug is used most commonly for large virilizing adrenal tumors that cannot be surgically removed.Ketoconazole (Nizoral), an orally effective broadspectrum antifungal agent, blocks hydroxylating enzyme systems by interacting with cytochrome P450 at the heme iron site to inhibit steroid and/or androgen synthesis in adrenals, gonads, liver, and kidney. The most sensitive site of action appears to be the C17-20 lyase reaction involved in the formation of sex steroids. This explains the greater suppressibility of testosteron production than with cortisol. Cholesterol side-chain cleavage and 11β/18-hydroxylase are secondary sites of inhibition.

 

Product Parameters

 

 

Chemical & Physical Properties
 

Density1.4±0.1 g/cm3
Boiling Point753.4±60.0 °C at 760 mmHg
Melting Point146°C
Molecular FormulaC26H28Cl2N4O4
Molecular Weight531.431
Flash Point409.4±32.9 °C
Exact Mass530.148743
PSA69.06000
LogP3.55
Vapour Pressure0.0±2.5 mmHg at 25°C
Index of Refraction1.642

China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

Storage:

1. Stored in a clean, cool and dry area; keep away from strong, direct light.

2. Shelf Life is 2 years when properly stored.

 

Packing:
1. Inner double plastic bags----25kg/Fiber drum (36*36*45cm, GW: 28kg, NW: 25kg);

2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).

3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).


P.S.: we accept packaging customization.

 

Delivery:

1. In stock products are normally shipping within 3 working days.

2. For rush delivery, please contact our sales team for particular arrangement
China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

 

Shipping:

1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.

2. Shipping details & shipping documents will be provided and sent by email.

3. We keep tracking the shippment until clients well received.

4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.

China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm FungarestChina Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm FungarestChina Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm FungarestChina Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

Hot sell products:

CHEMICAL NAMECAS No.STATEPRICEFREE SAMPLE
Benzocaine94-09-7IN STOCKNegotiableAvailable
Benzocaine HCI23239-88-5IN STOCKNegotiableAvailable
Lidocaine 137-58-6IN STOCKNegotiableAvailable
Lidocaine hydrochloride73-78-9 IN STOCKNegotiableAvailable
Tetracaine94-24-6IN STOCKNegotiableAvailable
Boric acid 11113-50-1IN STOCKNegotiableAvailable
Levamisole (hydrochloride)16595-80-5IN STOCKNegotiableAvailable
Procaine (HCI)51-05-8IN STOCKNegotiableAvailable
Procaine 59-46-1IN STOCKNegotiableAvailable

Payment term:

We accept various payment terms, the main methods are : T/T, L/C, Western Union, credit card, Bitcoin, USDT etc.
China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

Shipping term:
China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

Our Advantages

China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest
WHY CHOOSE US
MU LEI (Wuhan) is committed to helping clients reach their goals, to providing high quality products and efficient shipments.

Our strong sense of responsibility with client projects means that we are constantly striving to provide solutions, even for issues they aren't yet aware of.

This sense of responsibility also means we value and promote seamless interaction with clients, and ensure the best value is obtained from their research budget.

Our staff bring professional knowledge to clients, as well as efficient responding to the clients, have built long-term cooperated relationships.
China Best Supplier Ketoconazole Powder CAS 65277-42-1 Fungoral Onofin K Nizoral Ketoderm Fungarest

FAQ

In this page, we will continue to update frequently asked questions and answers about the crystaline, Benzocaine powder, Lidocaine hcl powder, Procaine hcl crystal, fluffy Lidocaine, tetracaine chemical, Crystalline tetramisole hydrochloride, and so on, Stay tuned....

  • QWhat's your advantage?

    A

    The series of natural extracted product are all self-developed, produced and tested. Mature production technology, strict quality management system and cost control system, ensure the product stability and competitive price.

  • QHow to deal with quality complaints or the goods get loss?

    A

    Firstly, every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA (or depends on customers' request).


    If it is our product quality issue or due to the force majeures, we will send you another shipment for free.
     

  • QIs there any discount?

    AThe price is negotiable. The more bigger quantity you order, the more competitive price you would get.
     

  • QHow do you manage the delivery?

    AGoods will be shipped within 24 hours (Chinese public holiday are excluded), usually shipping by DHL, Fedex, EMS, TNT, HKETK. We will ship with the special safe channel to ensure you getting goods on time.

  • QHow to place an order?

    AInquiry + payment + shipping.

    Firstly, please send inquiry infor to us, including quantity, your target price, shipping method, packing request, destination etc.     We will reply you the quotation and lead time within 1-8 hours (different time zone).

    Second, pay for the order, we accept various payment terms, the main methods are: T/T, L/C, Western Union, credit card, BitCoin, USDT, Money Gram.

    After received the payment, we will ship out products immediately and share tracking number with you.

    And for sure, we keep tracking the shippment, and we provide after-service.
     

  • QCan I get some samples?

    AWarmly welcome, we can provide samples for free, but the shipping cost will be covered by customers.


 

You Might Also Like