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High-Purity Pharmaceutical Grade Citrus Extract Diosmin

China High-Purity Pharmaceutical Grade Citrus Extract Diosmin, Find details about China Medicinal Raw Materials, Natural Extract from High-Purity Pharmaceutical Grade Citrus Extract Diosmin

Function
Keeping Health and Promoting Growth
Appearance
Powder
Product
Powdery High Purity Extract
Trademark
IKNOW
Transport Package
Foil Bag/Drum/as Per Your Request
Specification
EP8.3, Non-micronized powder
Origin
China
Function
Keeping Health and Promoting Growth
Appearance
Powder
Product
Powdery High Purity Extract
Trademark
IKNOW
Transport Package
Foil Bag/Drum/as Per Your Request
Specification
EP8.3, Non-micronized powder
Origin
China
High-Purity Pharmaceutical Grade Citrus Extract Diosmin

Description

Diosmin is a flavone, a member of the flavonoid family. Diosmin aglycone is diosmetin. It can be found in Teucrium gnaphalodes, a plant endemic to the Iberian Peninsula.

Diosmin is a semisynthetic flavonoid molecule derived from citrus d (modified hesperidin). It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) including spider and varicose veins, leg swelling (edema), stasis dermatitis and venous ulcers. It is also used as a stand-alone or surgical adjunctive therapy in hemorrhoidal disease (HD).

High-Purity Pharmaceutical Grade Citrus Extract Diosmin
Basic Information
 
 Product Name Diosmin
 Source Citrus
 Specification EP8.3,Non-micronized powder
 Appearance Hygroscopic Powder
 Storage It should be stored in a dry, clean, light-free environment
 Packing 25kg
 Shelf life 2 years
 Applications Capsules, tablets, granules, etc.

Product Specification
 
ProductDiosmin
AppearanceHygroscopic Powder
Color Grayish yellow or light yellow
Molecular Weight 608.54
CAS NO.520-27-4
Molecular Formula C28H32O15
Country of Origin China
CertificateCEP, KOSHER, ISO9001, ISO22000
Test SpecificationsTS-10017-00/Ph.Eur. 8.3
SolubilityPractically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides
Iodine≤0.1%
Solution NaOH 1N ≤0.3
Density ≥0.5 g/ml
Related Substances (HPLC)Impurity A(Acetoisovanillone)≤0.5%
Impurity B (Hesperidin)≤4.0%
Impurity C (Isorhoifolin)≤3.0%
Impurity D (6-iodo-diosmin)≤0.6%
Impurity E(Linarin)≤3.0%
Impurity F (Diosmetin)≤2.0%
Unspecified Impurities ≤0.4%
Total impurities≤8.5%
Heavy metalsnts≤20ppm
Particle size Micronized (95% < 5microns)
Water≤6.0%
Assay on anhydrous basis90.0%~102.0%
Packing 25kg
Production Capacity 10MT/Month

Function
 
Diosmin is a nutrient that is widely contained in citrus and that has been indicated to improve glucose metabolism in diabetic disorders. Recently, we demonstrated that diosmin induces β-endorphin to lower hyperglycemia in diabetic rats. However, the mechanisms of diosmin in opioid secretion were unclear. Therefore, we focused on the secretion of opioids from isolated adrenal glands induced by diosmin. The changes in the released β-endorphin-like immunoreactivity (BER) were determined using ELISA. Diosmin increased the BER level in a dose-dependent manner, and this effect was markedly reduced in the absence of calcium ions. Activation of the imidazoline I-2 receptor (I-2R) has been introduced to induce opioid secretion. Interestingly, we observed that diosmin activates CHO cells expressing I-R. 

Packing & Shipment

High-Purity Pharmaceutical Grade Citrus Extract Diosmin


High-Purity Pharmaceutical Grade Citrus Extract DiosminHigh-Purity Pharmaceutical Grade Citrus Extract Diosmin
Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.
High-Purity Pharmaceutical Grade Citrus Extract Diosmin

Certification

High-Purity Pharmaceutical Grade Citrus Extract Diosmin

High-Purity Pharmaceutical Grade Citrus Extract Diosmin

High-Purity Pharmaceutical Grade Citrus Extract Diosmin
 
Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. 

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your los

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