1. For gastroesophageal reflux disease (GERD).
2.Treatment of erosive reflux esophagitis in 2. cases.
3. long term maintenance of relapse in patients with esophagitis who have been cured.
4. Symptom control of gastroesophageal reflux disease (GERD) 
5. combined with appropriate antimicrobial therapy for the eradication of Helicobacter pylori infection related peptic ulcer healing, and to prevent recurrence.
6. the risk of gastric ulcer is reduced in patients receiving continuous NSAID treatment.
7. for the treatment of liver and stomach of the chest and diaphragm, stomach burning pain.
8. for the treatment of stomachache Tunsuan, dysphagia, hiccup.
The primary uses of esomeprazole are gastroesophageal reflux disease, treatment and maintenance of erosive esophagitis, treatment of duodenal ulcers caused by H. pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and treatment of gastrointestinal ulcers associated with Crohn's disease.