99% Purity CAS 103060-53-3 Daptomycin Antibiotic Daptomycin Powder Material Daptomycin
China 99% Purity CAS 103060-53-3 Daptomycin Antibiotic Daptomycin Powder Material Daptomycin, Find details about China Daptomycin, Purity Daptomycin from 99% Purity CAS 103060-53-3 Daptomycin Antibiotic Daptomycin Powder Material Daptomycin
Basic Info.
Model NO.
D-sung Daptomycin
Product Name
Daptomycin
Name
Daptomycin Powder
Appearance
White Powder
Color
White
Grade
Pharmaceutical Grade
Assay
HPLC 99%
Application
Pharmaceutical;Antibiotic
Specific
COA
Test Method
HPLC
Shelf Life
2 Years
CAS No.
103060-53-3
Mf
C72h101n17o26
MW
1620.693
Melting Point
202-204°c
Density
1.45
Trademark
D-sung
Transport Package
Negotiable
Specification
99%
Origin
Shaanxi Xi′an
Model NO.
D-sung Daptomycin
Product Name
Daptomycin
Name
Daptomycin Powder
Appearance
White Powder
Color
White
Grade
Pharmaceutical Grade
Assay
HPLC 99%
Application
Pharmaceutical;Antibiotic
Specific
COA
Test Method
HPLC
Shelf Life
2 Years
CAS No.
103060-53-3
Mf
C72h101n17o26
MW
1620.693
Melting Point
202-204°c
Density
1.45
Trademark
D-sung
Transport Package
Negotiable
Specification
99%
Origin
Shaanxi Xi′an
Product Desciption
99% Purity CAS 103060-53-3 Daptomycin Antibiotic Daptomycin Powder Material Daptomycin
| Product name | Daptomycin |
| Appearance | Off-white to light yellow powder |
| CAS NO. | 103060-53-3 |
| MF | C72H101N17O26 |
| MW | 1620.693 |
| Melting point | 202-204°C |
Daptomycin is the first entry of a new class of cyclic lipopeptide antibiotics that disrupts multiple aspects of bacterial membrane function including disruption of membrane potential and amino acid transport, inhibition of lipoteichoic acid synthesis and inhibition of peptidoglycan synthesis. It is indicated for the treatment of complicated skin and skinstructure infections (cSSSI) caused by a range of Gram-positive bacteria. This is distinct from previous classes of antibiotics that inhibit bacterial cell wall biosynthesis, bacterial DNA replication, and folate coenzyme biosynthesis. Due to this unique mechanism, cross-resistance has not been noted with any other class of antibiotics.
Daptomycin is from Streptomyces (S.reseosporus) extracted from cyclic lipopeptide antibiotics a new structure of the fermentation broth, it not only has a novel chemical structure, and the mode of action and any one of the approved antibiotics are different: it is through the transport of amino acids disrupt the cell membrane, thus impeding the biosynthesis of bacterial cell wall peptidoglycan, change the nature of cell membrane, can damage the function of bacterial cell membrane in many aspects, and quickly kill gram positive bacteria.
In addition to the role of daptomycin in most clinically relevant gram positive bacteria, it is more important to have in vitro showed methicillin resistant (methicillin) strains, vancomycin and linezolid resistant properties with potent activity for this feature has very important clinical significance in patients with severe infection.
The research shows that the antibacterial spectrum of activity is similar to vancomycin and daptomycin, mainly has a strong antimicrobial effect on Gram positive bacteria, such as Staphylococcus aureus spp MIC=0.125 ~ 0.5 g/ml, the gram bacteria spp MIC=0.06 ~ 0.5 g/ml, 0.25 MIC= of Enterococcus to 2 mu g/ ml. Daptomycin has broad-spectrum antibacterial activity in the gram positive anaerobic bacteria on spp. MIC=0.12, Peptostreptococcus g/ml, spp.MIC=0.5 of Clostridium g/ml of Lactobacillus spp.MIC=1 g/ml.
Daptomycin is from Streptomyces (S.reseosporus) extracted from cyclic lipopeptide antibiotics a new structure of the fermentation broth, it not only has a novel chemical structure, and the mode of action and any one of the approved antibiotics are different: it is through the transport of amino acids disrupt the cell membrane, thus impeding the biosynthesis of bacterial cell wall peptidoglycan, change the nature of cell membrane, can damage the function of bacterial cell membrane in many aspects, and quickly kill gram positive bacteria.In addition to the role of daptomycin in most clinically relevant gram positive bacteria, it is more important to have in vitro showed methicillin resistant (methicillin) strains, vancomycin and linezolid resistant properties with potent activity for this feature has very important clinical significance in patients with severe infection.
The research shows that the antibacterial spectrum of activity is similar to vancomycin and daptomycin, mainly has a strong antimicrobial effect on Gram positive bacteria, such as Staphylococcus aureus spp MIC=0.125 ~ 0.5 g/ml, the gram bacteria spp MIC=0.06 ~ 0.5 g/ml, 0.25 MIC= of Enterococcus to 2 mu g/ ml. Daptomycin has broad-spectrum antibacterial activity in the gram positive anaerobic bacteria on spp. MIC=0.12, Peptostreptococcus g/ml, spp.MIC=0.5 of Clostridium g/ml of Lactobacillus spp.MIC=1 g/ml.
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