API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate

China API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate, Find details about China Loteprednol Etabonate, Loteprednol Etabonate Powder from API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate

Basic Info.

Model NO.

Condavo-Loteprednol Etabonate

Name

Loteprednol Etabonate

Product Name

Loteprednol Etabonate Powder

Appearance

White Powder

Color

White Color

Storage

Cool Dry Place

Shelf Life

2 Years

Assay

99%

CAS

82034-46-6

C24h31clo7

466.955

Density

1.31 G/Cm

Melting Point

220.5-223.5

Boiling Point

600.1c at 760 Mmhg

Refractive Index

1.57

Flash Point

316.7c

Trademark

Condavo

Transport Package

1kg/ Aluminium Bag or 25kg/Drum; as Required

Specification

99%

Origin

Shaanxi

Model NO.

Condavo-Loteprednol Etabonate

Name

Loteprednol Etabonate

Product Name

Loteprednol Etabonate Powder

Appearance

White Powder

Color

White Color

Storage

Cool Dry Place

Shelf Life

2 Years

Assay

99%

CAS

82034-46-6

C24h31clo7

466.955

Density

1.31 G/Cm

Melting Point

220.5-223.5

Boiling Point

600.1c at 760 Mmhg

Refractive Index

1.57

Flash Point

316.7c

Trademark

Condavo

Transport Package

1kg/ Aluminium Bag or 25kg/Drum; as Required

Specification

99%

Origin

Shaanxi

Product Desciption

API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate

API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate

Product Name	Loteprednol Etabonate
CAS	82034-46-6
Appearance	White crystalline powder
MF	C24H31ClO7
MW	466.955
Purity	99%
Shelf Life	2 Years

Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used to treat inflammations of the eye. It is marketed by Bausch and Lomb as Lotemax. Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.IC50 Value:Target: Glucocorticoid Receptorin vitro:in vivo: Intravenous administration of loteprednol etabonate (5 mg/kg) to dogs revealed a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect. A pronounced binding of the drug to plasma protein (> 90%) and a high erythrocyte-buffer partition coefficient of 7.8 were determined in vitro.

API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate

API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate Common adverse effects include foreign body sensation in the eye, dry eye and epiphora (overflow of tears), chemosis (swelling of the conjunctiva), headache, and itching. Increased intraocular pressure (IOP), a side effect typical of corticosteroids, occurs in about 2% of patients (compared to 7% under prednisolone acetate, an older anti-inflammatory agent which is prescribed after eye surgery, and 0.5% under placebo).
API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate

Loteprednol etabonate is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitis. It is used in ophthalmic ointment for the treatment of post-operative inflammation and pain following ocular surgery. As a nasal spray, it is used for the treatment and management of seasonal allergic rhinitis.

API Anti-Inflammatory Loteprednol Etabonate Purity Loteprednol Etabonate Powder Loteprednol Etabonate