Main ingredients: Enrofloxacin. this product is white or light yellow powder.
[pharmacological action] pharmacodynamics enrofloxacin is a kind of broad-spectrum bactericidal antibacterial drug for animals. It has good effects on E.coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, erysipelas, proteus, Serratia mucosa, Corynebacterium pyogenes, botulinum septicum, Staphylococcus aureus, mycoplasma and chlamydia, etc., weak effects on Pseudomonas aeruginosa and Streptococcus, weak effects on anaerobic bacteria. It has obvious antibacterial effect on sensitive bacteria. The antibacterial mechanism of this kind of drugs is to act on DNA rotary enzyme (type II topoisomerase) of bacterial cells, interfere with the replication, transcription, repair and recombination of bacterial DNA, and the bacteria can not grow and reproduce normally and die. Its effect is dependent on the drug concentration, and the best therapeutic effect can be achieved when the drug concentration is more than 8 times mic.
Pharmacokinetic most single stomach animals can absorb this product very well, the blood concentration reaches the peak within 0.5-2 hours, and the food in the stomach can delay the drug absorption rate, but does not affect the absorption amount. The bioavailability was 62.2% - 84%. The product is widely distributed in animals and can enter tissues and body fluids (including bones and prostate). Except for the concentration of cerebrospinal fluid is only 6% - 10% of serum concentration, the drug concentration in almost all tissues is higher than that in plasma, and can accumulate 140 times of plasma concentration in leukocytes. The main metabolism of liver is to remove the ethyl of 7-piperazine ring to produce ciprofloxacin, followed by oxidation and glucuronic acid binding. Elimination was mainly excreted by the kidney (excretion of renal tubules and glomerular filtration), 15% - 50% of which was excreted from the urine in its original form. The half-life of chicken was 9.1-14.2 hours.
[drug interaction]
1.it has synergistic effect with aminoglycosides and broad-spectrum penicillin.
2.Ca2 +, Mg2 +, Fe3 +, Al3 + and other heavy metal ions can chelate with the product, affecting absorption.
3.When combined with theophylline and caffeine, the metabolism of the latter was inhibited, the concentration of theophylline and caffeine in the blood was increased abnormally, and even theophylline poisoning symptoms appeared. 4.It has the function of inhibiting the liver drug enzyme. When combined with the drugs metabolized in the liver, it can reduce the clearance rate and increase the blood drug concentration.
5.Propionate can inhibit the excretion of renal tubules and prolong its half-life.
[function and use] fluoroquinolones. It is used for avian bacterial diseases and mycoplasma infection.
[usage and dosage] calculated by this product. Mixed drink: 0.25-0.75g per 1L of water. Twice a day for 3-5 consecutive days.
[adverse reactions] (1) the cartilage of young animals can be denatured, causing postscript and pain.
(2) The reaction of digestive system includes vomiting, abdominal pain and distention.
(3) Skin reactions include erythema, pruritus, urticaria and photosensitive reactions.
[note] laying period is forbidden.
[rest period] chicken 8 days.
[Specification] 10%
[packaging] aluminum plastic bag, 100g / bag.
[approval No.] veterinary medicine No. 161012526
[storage] store in a dry place under the sun.