China Pharmaceutical Chemical Ingredients Raw Powder Procaine Base Procaine CAS 59-46-1, Find details about China Procaine with Hydrochloride, Procaine Pharmaceutical from China Pharmaceutical Chemical Ingredients Raw Powder Procaine Base Procaine CAS 59-46-1
Mechanism of action
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Test Items | Specification | Test Results |
Appearance | White crystals or a white crystalline powder | Conform |
Identification | ABE. It appears positive reaction | |
Melting point | 154degree~158degree | 154degree~157degree |
Acidity | PH 5.0~6.5 | PH=5.9 |
Appearance of solution | Clear and colourless | Conform |
Loss on drying | ≤0.5% | 0.07% |
Heavy metals | ≤0.0005% | Conform |
Related substances | ≤0.05% | Conform |
Sulphated ash | ≤0.1% | 0.05% |
Assay ( on dry basis ) | 99.0-101.0% | 99.87% |
Conclusion | Conform to BP2005 |
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