Guggulsterone is a phytosteroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein increased in many people. Nevertheless, guggulsterone is an ingredient in many nutritional supplements.

1. Guggulsterones E&Z for High cholesterol: Studies show that a 14-27% of LDL cholesterol and 22-30% of triglycerides levels were reduced when guggul was given to men and women with high cholesterol for 12 weeks with no change in diet or exercise. Several clinical studies were published in the Indian Journal of Medicine (volume 84) in 1986, Indian Pharmacoepia and in the Journal of the Association of Physicians in India (vol. 34 & 37) all stating the efficacy of guggul in lowering LDL cholesterol and triglycerides.
 

2. Guggulsterones E&Z for Atherosclerosis: Two compounds, Z-guggulsterone and E-guggulsterone, appear to be responsible for guggul lipid's cholesterol- lowering effects. Guggul also appears to boost levels of "good" cholesterol although the exact mechanism is unknown. Both of these actions help prevent Atherosclerosis. Guggul is also an antioxidant, which helps stop the oxidization of cholesterol and the subsequent hardening of the arteries.
 

3. Guggulsterones E&Z for Impotence: Men with lower blood cholesterol or higher amounts of the beneficial high-density lipoprotein (HDL) cholesterol may be less likely to develop erectile dysfunction or impotence. Since guggul supports atherosclerosis (hardening of the arteries), which may impede blood flow to and from the penis, guggul may possibly be the treatment for impotence many men are looking for.
 

4. Guggulsterones E&Z for Weight Loss: Research with laboratory animals suggests guggul may help enhance thyroid function. Since the thyroid gland produces hormones that are needed to regulate metabolism, it can help in weight loss.