Supply Ability
Supply Ability:100000 Kilogram/Kilograms per Month
Supply Ability: 1000 Ton/Tons per Year .
Product Description
Product Description
Product Name | Nicotinamide Adenine Dinucleotide |
Appearance | White Powder |
Molecular Weight | 663.43 |
Certificate | ISO9001/Halal/Kosher |
Specification | 98% |
Application | health care products |
MOQ | 10 G |
Function | Anti-aging |
Test Method | HPLC |
COA | Avalibale |
What is Beta-Nicotinamide Adenine Dinucleotide (NAD+)?
NAD,Nicotinamide adenine dinucleotide is a indispensable cofactor involved in several redox reactions in all forms of cellular life. It exists in two forms: an oxidized and reduced form abbreviated as NAD+ and NADH respectively.
NAD+ is an oxidizing agent - it accepts electrons from other molecules and becomes reduced. This reaction forms NADH, which can then be used as a reducing agent to donate electrons.Both of these two stabilized form of NAD are marketed as a anti-age nutritional supplement, which is not under FDA regulation at the moment.
Beta-Nicotinamide Adenine Dinucleotide (NAD+) Benefits
NAD+/NADH plays a significant role in the reactions associated with glycolysis, oxidative phosphorylation, and fermentation. Nicotinamide adenine dinucleotide(NAD) effects include the stimulation of dopamine, noradrenaline, and serotonin receptors, by which mechanism it is thought to increase mental alertness and clarity and improve concentration.
In the jet lag study, subjects who received NADH had significantly better cognitive performance and a trend toward reduced sleepiness on the first post-flight day than controls, and a smaller pilot study showed similar trends lasting through the second day.
In 2000, Guarente's lab reported that NAD fuels the activity of sirtuins, including SIRT1-the more NAD there is in cells, the more SIRT1 does beneficial things. One of those things is to induce formation of new mitochondria. NAD can also activate another sirtuin, SIRT3, which is thought to keep mitochondria (Mitochondria are our cells' energy dynamos. Descended from bacteria that colonized other cells about 2 billion years, they get flaky as we age) running smoothly.
Beta-Nicotinamide Adenine Dinucleotide (NAD+) Mode of Action
Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as acoenzyme inredox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of thesecond messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. In addition to these metabolic functions, NAD+ emerges as an adenine nucleotide that can be released from cells spontaneously and by regulated mechanisms, and can therefore have important extracellularroles.
The enzymes that make and use NAD+ and NADH are important in both pharmacology and the research into future treatments for disease. Drug design and drug development exploits NAD+ in three ways: as a direct target of drugs, by designing enzyme inhibitors or activators based on its structure that change the activity of NAD-dependent enzymes, and by trying to inhibit NAD+biosynthesis.
The coenzyme NAD+ is not itself currently used as a treatment for any disease. However, it is being studied for its potential use in the therapy of neurodegenerative diseases such asAlzheimer's andParkinson disease. Evidence on the benefit of NAD+ in neurodegeneration is mixed; some studies inmice have produced promising results whereas a placebo-controlled clinical trial in humans failed to show any effect.
NAD+ is also a direct target of the drug isoniazid, which is used in the treatment oftuberculosis, an infection caused by Mycobacterium tuberculosis. Isoniazid is a prodrug and once it has entered the bacteria, it is activated by a peroxidase enzyme, which oxidizes the compound into a free radicalform. This radical then reacts with NADH, to produce adducts that are very potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolate reductase. In one experiment, mice given NAD for one week had improved nuclear-mitochrondrial communication.
Detailed Photos
Our Advantages
Full experience of large numbers containers loading in Chinese sea port
Fast shipent by reputed shipping line
Packing with pallet as buyer's special request
Cargoes together with container sales service available
Cargoes photo before and after loading into container
Raw materials from Chinese origin
1.We will provide you with professional loading
2.We have one team supervise uploading the materials. We will check the container, the packages
3.Every step, taking pictures and make records.4.we will make a complete Loading Report for our customer of each shipmen
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Packaging & Shipping
PACKING & DELIVERYPackaging
Customized
Delivery
Usually within3-5 working days after full payment
Shipping
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;50KG, usually called as DDU service
Company Profile
Company Profile:
Hebei Ainuodi Technology Co., Ltd. has many years of export experience. The company has a registered capital of 5 million yuan. It specializes in the production of pharmaceutical intermediates, organic intermediates, Hehe, steroids, peptides, cosmetics, raw materials, pharmaceutical raw materials, other, carbomer , Organic Chemistry, Inorganic Chemistry, , etc. We have the most complete production line and provide high-quality and low-cost services. In addition, the products we developed have been sold to many countries in the world, including Europe, America, Australia, Southeast Asia, the Middle East and South Africa. The company has been implementing the "people-oriented" management model and adhering to the principle of "quality first, customer first"
FAQ
FAQ:
1. who are we?
We are based in Hebei, China, start from 2015,sell to Western Europe,Eastern Europe,North America,South America,Southern Europe,Southeast Asia,Oceania,Northern Europe,Central America,There are total about 51-100 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical Intermediate ,Organic Intermediate,Sar ms,Steroids, polypeptide, cosmetics, material,Pharmaceutical Ingredients,Others ,Carbomer,Organic chemicals,Inorganic chemicals,Wait
4. why should you buy from us not from other suppliers?
Hebei Ainodi Technology Co., Ltd.Company registered capital of 5 million yuan, the company has the most perfect production line, products are sold to Europe, America, Australia, Southeast Asia, the Middle East, South Africa and other more than 50 countrie
5. what services can we provide?
Accepted Delivery Terms: FOB,CFR,CIF,EXW,FAS,CIP,FCA,CPT,DEQ,DDP,DDU,Express Delivery,DES;
Accepted Payment Currency:USD,EUR,CNY,CHF;
Accepted Payment Type: T/T,L/C,D/P D/A,MoneyGram,Credit Card,PayPal,Western Union,Cash,Escrow;
Language Spoken:English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian