Pharmaceutical 99% CAS 25812 -30-0 Gemfibrozil Powder

China Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder, Find details about China 25812-30-0, CAS 25812-30-0 from Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder

Model NO.
25812-30-0
Storage Condition
Store at Rt
Trademark
FOUSI
Transport Package
Aluminium Foil Bag
Specification
kg
Origin
China
Model NO.
25812-30-0
Storage Condition
Store at Rt
Trademark
FOUSI
Transport Package
Aluminium Foil Bag
Specification
kg
Origin
China

 

Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder

Pharmaceutical 99% CAS 25812-30-0
Gemfibrozil Powder

 
Product Description
 
Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder
Product Name:Gemfibrozil
CAS:25812-30-0
MF:C15H22O3
MW:250.33
EINECS:247-280-2
Melting Point:61-63°C
Boiling point:158-159°C

Gemfibrozil, 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (Lopid), is a congener of clofibratethat was used first in the treatment of hyperlipoproteinemia inthe mid-1970s. Its mechanism of action and use are similar tothose of clofibrate. Gemfibrozil reduces plasma levels ofVLDL triglycerides and stimulates clearance of VLDL fromplasma. The drug has little effect on cholesterol plasma levelsbut does cause an increase of HDL.
 
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Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder

Product Parameters
 
ItemsStandardsResults
AppearanceWhite or off-white solid powderComplies
IdentificationBy IRComplies
By HPLCComplies
SolubilitySoluble in DMF, sparingly soluble in THF, slightly soluble in meth anol and aceto nitrile, very sightly soluble in ethanol and dichloro metha ne, insoluble in water.Complies
Polymorphic FormPolymorphic form 1Complies
Melting Point211ºC~216ºC212.8ºC~214.9ºC
Water Content≤ 0.50%0.10%
Heavy Metals≤ 20ppmComplies
Residue on Ignition≤ 0.20%0.09%
Related SubstanceAny single impurity: ≤0.10%0.06%
Total Impurities: ≤1.00%0.16%
Assay                  
(on the anhydrous basis)
98.0%~102.0%99.94%

Application

1. Used for the treatment of hyperlipidemia. The agent is suitable for treatment of severe type IV or type V hyperlipoproteinemia patients with high-risk coronary heart disease who had no response to treatments such as dietary control or weight loss. It is also applicable to type II-b hyperlipoproteinemia patients with high-risk coronary heart disease who had failed to respond to treatments such as dietary control, weight loss, or other lipid-regulating medications.

2. Used as a lipid-regulating agent. It can significantly reduce the levels of triglyceride and cholesterol in blood, and can significantly reduce very low-density lipoprotein (VLDL) levels and increase high-density lipoprotein (HDL) levels, but it has little effect on low-density lipoprotein (LDL) levels. Clinically, it can be used in patients with all types of lipid metabolism disorders, such as primary and secondary hyperlipoproteinemias, hypercholesterolemias, hypertriglyceridemias, mixed hyperlipidemias, and lipid metabolism disorders caused by diabetes. It can also be used to prevent the occurrence of myocardial infarction.

3. The product belongs to phenoxy aromatic acid antihyperlipidemics, which is a group of drugs developed on the basis of clofibrate including fenofibrate, Etofylline Clofibrate, Bijiangzhi, gemfibrozil and so on. These drugs were similar in chemical structure. Clofibrate has rather serious adverse reactions (which include elevating the occurrence of gallstone). Improved drugs are more effective than clofibrate, with mild and fewer adverse reactions.

4. A lipid-regulating drug that can reduce cholesterol and triglyceride levels in blood.
 
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Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder

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Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil PowderPharmaceutical 99% CAS 25812-30-0 Gemfibrozil PowderPharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder
 
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Pharmaceutical 99% CAS 25812-30-0 Gemfibrozil Powder