China OEM Pharmaceutical Raw Material Buflomedil HCl in Stock, Find details about China Free Sample Buflomedil HCl, Quality Control Buflomedil HCl from OEM Pharmaceutical Raw Material Buflomedil HCl in Stock
Product Name: | Buflomedil HCl |
CAS: | 35543-24-9 |
MF: | C17H25NO4. HCl |
MW: | 343.85 |
Purity: | 99% Min |
Shelf Life | 2 years |
Appearance | White Powder |
Brand Name: | Oriherb |
Form | Powder |
Place of Origin: | Shaanxi, China (Mainland) |
Packaging: | Bottle, Can, Drum, Plastic Contain |
Standard: | USP EP JP etc. |
Introduction: | Buflomedil HCl is a vasodilator used to treat symptoms of claudication or peripheral arterial disease. It is a non-selective alpha adrenergic receptor inhibitor. |
Items | Standard | Results | |||||
Characters | White or almost white, microcrystalline powder. | Almost white, microcrystalline powder. | |||||
Melting point | About 195 °C, with decomposition. | 194.5~197.0°C | |||||
Identification | The solution shows an absorption maximum at 275 nm. The specific absorbance at the maximum is 143 to 149. | Qualified | |||||
IR | |||||||
TLC | |||||||
Gives reaction of chlorides | |||||||
Appearance of solution | Meets the requirements | Qualified | |||||
pH | 5.0~6.5 | 5.93 | |||||
Related substances | Individaul impurity≤0.25% | 0.01% | |||||
Total impurities≤0.5% | 0.02% | ||||||
Heavy metals | ≤0.001% | <0.001% | |||||
Loss on drying | ≤0.5% | 0.06% | |||||
Sulphated ash | ≤0.1% | 0.03% | |||||
Assay | 98.5%~101.5% | 99.15% | |||||
CONCLUSION: | The product complies to the standard of BP2010,EP6.0. |
1.Buflomedil increases intracellular levels of cAMP in human keratinocytes, either secondary to phosphodiesterase inhibition (PTX) or adenyl-cyclase stimulation (BC). Buflomedil diminishes TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level.
2. Buflomedil significantly inhibits epinephrine-induced aggregation at the micromolar level. Buflomedil results in a weak inhibition of ADP- and collagen-induced aggregation. Buflomedil inhibits granular secretion and the interaction of fibrinogen with its receptor on platelet.
1.Applied in food field; 2.Applied in health food field; 3.Applied in pharmaceutical field.
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