China Ready to Ship Research Chemical High Purity Raw Powder Minoxidil CAS 38304-91-5, Find details about China Minoxidil, CAS 38304-91-5 from Ready to Ship Research Chemical High Purity Raw Powder Minoxidil CAS 38304-91-5
Product Name | Minoxidil |
CAS No. | 38304-91-5 |
Apearance | White Crystal Powder |
Molecular Formula | C9H15N5O |
EINECS No. | 253-874-2 |
Molecular Weight | 209.25 |
Brand Name | Biocar |
Density | 1.1651 (rough estimate) |
Storage Condition | Store at RT |
Melting Point | 272-274 °C (dec.) (lit.) |
Shelf Life | 2 Years |
Delivery Time | 7-10 Days |
Product Description:
Minoxidil is a white or quasi-white crystalline powder, slightly soluble in water or chloro-form, slightly soluble in ethanol, microchemicalbook soluble in ace-tone, soluble in glacial acetic acid It can directly act on the blood vessel wall, expand small arteries, reduce peripheral resistance, reduce blood pressure, and also increase heart rate and cardiac output, but its antihypertensive effect is more significant and lasting than that of hydrazine.
Minoxidil directly dilates the arteriole, thus lowering blood pressure, but the specific mechanism is not clear. Minoxidil does not dilate the peripheral blood vessels, resulting in increased reflex heart rate, increased cardiac output and increased renin activity, resulting in water and sodium retention. Minoxidil does not interfere with the Chemicalbook reflex of vascular motor, so orthostatic hypotension does not occur Minoxidil is a commonly used and effective drug in the treatment of hair loss, but its pharmacological action and its target cells are not very clear. In recent years, studies have shown that minoxidil may promote hair growth through the following ways.
Minoxidil is a kind of clinical oral medications for blood pressure, also known as long pressure Pp pyrimidine diamine step-down to determine blood min le, belong to the agent of potassium channels open, can directly relax vascular smooth muscle, small artery expansion has a powerful effect, make the peripheral resistance drop blood vessels dilate blood pressure to drop, and no influence on the capacity of the blood vessels, thus can promote the venous return At the same time, due to the reflexive Chemicalbook regulation and the positive frequency effect, the cardiac output and heart rate can be increased, but does not cause the postural hypotension for the clinical treatment of refractory hypertension and renal hypertension It can also be used for severe hypertension in which other antihypertensive drugs do not respond well, but it needs to be used in combination with diuretics to avoid water and sodium retention, and in combination with β-blockers to increase efficacy and reduce adverse reactions.
One of the side effects of long-term use of minoxidil is a slight increase in body hair, such as the hair on the arms, over time. But generally within acceptable limits.
The main adverse reactions of oral administration include: weight gain and lower limb edema caused by water and sodium retention, palpitation and arrhythmia caused by reflex sensory excitation, hypertrichosis, etc.
The main adverse reactions of topical preparations include skin irritation, erythema, itching and other dermatitis at the site of medication. Although the amount absorbed in topical preparations is very small, an effect on the condition of patients with a history of heart disease cannot be ruled out. Chemicalbook should be used with caution in patients with cerebrovascular disease, non-hypertensive heart failure, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases. Chemicalbook should not be used in patients with minoxidil allergy or pheochromocytoma.
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