Gabapentin is an anti-epileptic drug, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in
the cause of seizures and some types of pain. Gabapentin is also used to treat neuropathic pain (nerve pain) caused by herpes
virus or shingles (herpes zoster) in adults.

Product Name: Gabapentin
Synonyms: NEURONTIN;GABAPENTINE;GABAPENTIN HYDROCHLORIDE;GABAPENTIN;GOE-3450;(1-AMINOMETHYL-CYCLOHEXYL)-ACETIC ACID;1-(AMINOMETHYL)CYCLOHEXANEACETIC ACID
CAS: 60142-96-3
MF: C9H17NO2
MW: 171.24
EINECS: 262-076-3
Melting point: 162°C
Boiling point: 314.4±15.0 °C
Storage temp.: Desiccate at +4°C

Description:

Gabapentin was introduced in 1993 in the UK and early 1994 in the USA as an adjunctive therapy in the treatment of refractory partial seizures and secondarily generalized tonic-clonic seizures. Although being a lipophilic analog of the neurotransmitter GABA, gabapentin appears to exert its anticonvulsive function by a GABA receptor independent mechanism, possibly involving the L-system amino acid transporter protein. Gabapentin easily crosses the blood brain barrier and exhibits a favorable pharmacokinetic profile with high tolerability.

It does not interfere with the metabolism of other concomitant administered antiepileptic drugs, thus having a low potential for drug interactions. Studies are currently underway for the use of gabapentin as mono-therapy for the treatment of various seizures.

Gabapentin is structurally similar to GABA (sc-203053; γ-aminobutyric acid) and is reported in various research studies to increase GABA concentrations within the brain.

Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels.

Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, preventneuronal cell death, and is antinociceptive.

Gabapentin is an anti-epileptic medication, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.

Gabapentin is used in adults to treat nerve pain caused by herpes virus or shingles (herpes zoster).

Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.

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