Docetaxel is one of the taxane type drugs that were originally developed from the yew tree. Docetaxel is a man made drug that was first made from yew tree needles. It is also known by its brand name, Taxotere. It works by stopping the cancer cells from separating into 2 new cells, so it blocks the growth of cancer.

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent.

1.Docetaxel is a clinically well established antimitotic chemotherapy medication (that is, it interferes with cell division).

2.Docetaxel is used mainly for the treatment of breast, ovarian, and non-small cell lung cancer.

3.Docetaxel has an FDA approved claim for treatment of patients who have locally  advanced, or metastatic  breast or non small cell lung cancer who have undergone anthracycline based chemotherapy and failed to stop cancer progression or relapsed. An European approval  docetaxel for use in hormone refractory 

prostate cancer. 

4.Docetaxel is considered better than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule. 

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